TY - GEN
T1 - Simulation of chemotaxis-based sorting of heterotypic cell populations
AU - Eyiyurekli, Manolya
AU - Lelkes, Peter I.
AU - Breen, David E.
PY - 2007
Y1 - 2007
N2 - Cell sorting is a fundamental process that is involved in early embryo development, tumerogenesis and morphogenesis. The sorting of heterotypic cell populations is produced by a variety of inter-cellular actions, e.g. differential adhesion and motility. We recently developed a software system that simulates chemotaxis-based cell aggregation in 2D. The model implemented within the system includes a variety of physiological cell behaviors, such as chemical diffusion/detection, motility, proliferation, adhesion and life cycle stages. In this paper we extend the model to simulate heterotypic cell sorting. This paper provides an overview of the chemotaxis-based aggregation model and describes the parameters and processes utilized to simulate the sorting of two different cell populations based on chemotactic interactions.
AB - Cell sorting is a fundamental process that is involved in early embryo development, tumerogenesis and morphogenesis. The sorting of heterotypic cell populations is produced by a variety of inter-cellular actions, e.g. differential adhesion and motility. We recently developed a software system that simulates chemotaxis-based cell aggregation in 2D. The model implemented within the system includes a variety of physiological cell behaviors, such as chemical diffusion/detection, motility, proliferation, adhesion and life cycle stages. In this paper we extend the model to simulate heterotypic cell sorting. This paper provides an overview of the chemotaxis-based aggregation model and describes the parameters and processes utilized to simulate the sorting of two different cell populations based on chemotactic interactions.
UR - http://www.scopus.com/inward/record.url?scp=50849122016&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000255229500062&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1109/LSSA.2007.4400931
DO - 10.1109/LSSA.2007.4400931
M3 - Conference contribution
SN - 9781424418138
T3 - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
SP - 249
EP - 252
BT - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
PB - IEEE Computer Society
T2 - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
Y2 - 8 November 2007 through 9 November 2007
ER -