Abstract
Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).
| Original language | English |
|---|---|
| Pages (from-to) | 256-264 |
| Number of pages | 9 |
| Journal | Current Opinion in Immunology |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1999 |
Keywords
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- B-Lymphocytes/immunology
- Calcium-Calmodulin-Dependent Protein Kinases/metabolism
- Carrier Proteins/metabolism
- GTP-Binding Proteins/metabolism
- GTPase-Activating Proteins
- Humans
- Models, Biological
- Phosphatidylinositol 3-Kinases/metabolism
- Phosphoproteins/metabolism
- Receptors, Antigen, B-Cell/chemistry
- Signal Transduction/immunology
- ras Proteins/metabolism
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