Signal transduction from the B cell antigen-receptor

Kerry S. Campbell

doi:10.1016/S0952-7915(99)80042-9

Signal transduction from the B cell antigen-receptor

Kerry S. Campbell

Research output: Contribution to journal › Article › peer-review

185 Scopus citations

Abstract

Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).

Original language	English
Pages (from-to)	256-264
Number of pages	9
Journal	Current Opinion in Immunology
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/S0952-7915(99)80042-9
State	Published - 1999

Keywords

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Animals
B-Lymphocytes/immunology
Calcium-Calmodulin-Dependent Protein Kinases/metabolism
Carrier Proteins/metabolism
GTP-Binding Proteins/metabolism
GTPase-Activating Proteins
Humans
Models, Biological
Phosphatidylinositol 3-Kinases/metabolism
Phosphoproteins/metabolism
Receptors, Antigen, B-Cell/chemistry
Signal Transduction/immunology
ras Proteins/metabolism

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10.1016/S0952-7915(99)80042-9

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title = "Signal transduction from the B cell antigen-receptor",

abstract = "Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).",

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AB - Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).

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KW - Amino Acid Sequence

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KW - B-Lymphocytes/immunology

KW - Calcium-Calmodulin-Dependent Protein Kinases/metabolism

KW - Carrier Proteins/metabolism

KW - GTP-Binding Proteins/metabolism

KW - GTPase-Activating Proteins

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KW - Models, Biological

KW - Phosphatidylinositol 3-Kinases/metabolism

KW - Phosphoproteins/metabolism

KW - Receptors, Antigen, B-Cell/chemistry

KW - Signal Transduction/immunology

KW - ras Proteins/metabolism

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Signal transduction from the B cell antigen-receptor

Abstract

Keywords

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