Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

P. Zhang; H. B. Du; G. D. Tong; X. K. Li; X. H. Sun; X. L. Chi; Y. F. Xing; Z. H. Zhou; Q. Li; B. Chen; H. Wang; L. Wang; H. Jin; D. W. Mao; X. B. Wang; Q. K. Wu; F. P. Li; X. Y. Hu; B. J. Lu; Z. Y. Yang; M. X. Zhang; W. B. Shi; Q. He; Y. Li; K. P. Jiang; J. D. Xue; X. D. Li; J. M. Jiang; W. Lu; G. J. Tian; Z. B. Hu; J. C. Guo; C. Z. Li; X. Deng; X. L. Luo; F. Y. Li; X. W. Zhang; Y. J. Zheng; G. Zhao; L. C. Wang; J. H. Wu; H. Guo; Y. Q. Mi; Z. J. Gong; C. B. Wang; F. Jiang; P. Guo; X. Z. Yang; W. Q. Shi; H. Z. Yang; Y. Zhou; N. N. Sun; Y. T. Jiao; Y. Q. Gao; D. Q. Zhou; Y. A. Ye

doi:10.1111/jvh.12903

Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

P. Zhang, H. B. Du, G. D. Tong, X. K. Li, X. H. Sun, X. L. Chi, Y. F. Xing, Z. H. Zhou, Q. Li, B. Chen, H. Wang, L. Wang, H. Jin, D. W. Mao, X. B. Wang, Q. K. Wu, F. P. Li, X. Y. Hu, B. J. Lu, Z. Y. YangM. X. Zhang, W. B. Shi, Q. He, Y. Li, K. P. Jiang, J. D. Xue, X. D. Li, J. M. Jiang, W. Lu, G. J. Tian, Z. B. Hu, J. C. Guo, C. Z. Li, X. Deng, X. L. Luo, F. Y. Li, X. W. Zhang, Y. J. Zheng, G. Zhao, L. C. Wang, J. H. Wu, H. Guo, Y. Q. Mi, Z. J. Gong, C. B. Wang, F. Jiang, P. Guo, X. Z. Yang, W. Q. Shi, H. Z. Yang, Y. Zhou, N. N. Sun, Y. T. Jiao, Y. Q. Gao, D. Q. Zhou, Y. A. Ye

Cancer Prevention and Control (CPC)

Research output: Contribution to journal › Article › peer-review

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Abstract

The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n = 596), and HBeAg-negative chronic hepatitis B (n = 611). HBsAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HBsAg titres varied significantly in different phases (P =.000), with the highest (4.60 log10 IU/mL [10%-90% confidence interval: 3.52 log10 IU/mL-4.99 log10 IU/mL]) in patients with HBeAg-positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HBsAg level. In HBeAg-positive chronic hepatitis B patients, a negative correlation between HBsAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HBsAg titres in HBeAg-negative chronic hepatitis B patients. In conclusion, decreased HBsAg titres may be associated with advancing fibrosis in HBeAg-positive chronic hepatitis B patients or increased necroinflammation in those with HBeAg-negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HBsAg and provide useful insights into the management of this disease.

Original language	English
Pages (from-to)	1017-1025
Number of pages	9
Journal	Journal of Viral Hepatitis
Volume	25
Issue number	9
DOIs	https://doi.org/10.1111/jvh.12903
State	Published - Sep 2018

Keywords

Adult
Alanine Transaminase/blood
China
DNA, Viral/blood
Female
Hepatitis B Surface Antigens/blood
Hepatitis B e Antigens/blood
Hepatitis B, Chronic/complications
Humans
Liver Cirrhosis/pathology
Male
Middle Aged
Serum/chemistry
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/jvh.12903

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Zhang, P., Du, H. B., Tong, G. D., Li, X. K., Sun, X. H., Chi, X. L., Xing, Y. F., Zhou, Z. H., Li, Q., Chen, B., Wang, H., Wang, L., Jin, H., Mao, D. W., Wang, X. B., Wu, Q. K., Li, F. P., Hu, X. Y., Lu, B. J., ... Ye, Y. A. (2018). Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China. Journal of Viral Hepatitis, 25(9), 1017-1025. https://doi.org/10.1111/jvh.12903

@article{87d9b715e8574b3d88753216bf2abfaf,

title = "Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China",

abstract = "The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n = 596), and HBeAg-negative chronic hepatitis B (n = 611). HBsAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HBsAg titres varied significantly in different phases (P =.000), with the highest (4.60 log10 IU/mL [10%-90% confidence interval: 3.52 log10 IU/mL-4.99 log10 IU/mL]) in patients with HBeAg-positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HBsAg level. In HBeAg-positive chronic hepatitis B patients, a negative correlation between HBsAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HBsAg titres in HBeAg-negative chronic hepatitis B patients. In conclusion, decreased HBsAg titres may be associated with advancing fibrosis in HBeAg-positive chronic hepatitis B patients or increased necroinflammation in those with HBeAg-negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HBsAg and provide useful insights into the management of this disease.",

keywords = "Adult, Alanine Transaminase/blood, China, DNA, Viral/blood, Female, Hepatitis B Surface Antigens/blood, Hepatitis B e Antigens/blood, Hepatitis B, Chronic/complications, Humans, Liver Cirrhosis/pathology, Male, Middle Aged, Serum/chemistry, Young Adult",

author = "P. Zhang and Du, {H. B.} and Tong, {G. D.} and Li, {X. K.} and Sun, {X. H.} and Chi, {X. L.} and Xing, {Y. F.} and Zhou, {Z. H.} and Q. Li and B. Chen and H. Wang and L. Wang and H. Jin and Mao, {D. W.} and Wang, {X. B.} and Wu, {Q. K.} and Li, {F. P.} and Hu, {X. Y.} and Lu, {B. J.} and Yang, {Z. Y.} and Zhang, {M. X.} and Shi, {W. B.} and Q. He and Y. Li and Jiang, {K. P.} and Xue, {J. D.} and Li, {X. D.} and Jiang, {J. M.} and W. Lu and Tian, {G. J.} and Hu, {Z. B.} and Guo, {J. C.} and Li, {C. Z.} and X. Deng and Luo, {X. L.} and Li, {F. Y.} and Zhang, {X. W.} and Zheng, {Y. J.} and G. Zhao and Wang, {L. C.} and Wu, {J. H.} and H. Guo and Mi, {Y. Q.} and Gong, {Z. J.} and Wang, {C. B.} and F. Jiang and P. Guo and Yang, {X. Z.} and Shi, {W. Q.} and Yang, {H. Z.} and Y. Zhou and Sun, {N. N.} and Jiao, {Y. T.} and Gao, {Y. Q.} and Zhou, {D. Q.} and Ye, {Y. A.}",

note = "{\textcopyright} 2018 John Wiley & Sons Ltd.",

year = "2018",

month = sep,

doi = "10.1111/jvh.12903",

language = "English",

volume = "25",

pages = "1017--1025",

journal = "Journal of Viral Hepatitis",

issn = "1352-0504",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "9",

}

Zhang, P, Du, HB, Tong, GD, Li, XK, Sun, XH, Chi, XL, Xing, YF, Zhou, ZH, Li, Q, Chen, B, Wang, H, Wang, L, Jin, H, Mao, DW, Wang, XB, Wu, QK, Li, FP, Hu, XY, Lu, BJ, Yang, ZY, Zhang, MX, Shi, WB, He, Q, Li, Y, Jiang, KP, Xue, JD, Li, XD, Jiang, JM, Lu, W, Tian, GJ, Hu, ZB, Guo, JC, Li, CZ, Deng, X, Luo, XL, Li, FY, Zhang, XW, Zheng, YJ, Zhao, G, Wang, LC, Wu, JH, Guo, H, Mi, YQ, Gong, ZJ, Wang, CB, Jiang, F, Guo, P, Yang, XZ, Shi, WQ, Yang, HZ, Zhou, Y, Sun, NN, Jiao, YT, Gao, YQ, Zhou, DQ & Ye, YA 2018, 'Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China', Journal of Viral Hepatitis, vol. 25, no. 9, pp. 1017-1025. https://doi.org/10.1111/jvh.12903

TY - JOUR

T1 - Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation

T2 - A multicentre perspective in China

AU - Zhang, P.

AU - Du, H. B.

AU - Tong, G. D.

AU - Li, X. K.

AU - Sun, X. H.

AU - Chi, X. L.

AU - Xing, Y. F.

AU - Zhou, Z. H.

AU - Li, Q.

AU - Chen, B.

AU - Wang, H.

AU - Wang, L.

AU - Jin, H.

AU - Mao, D. W.

AU - Wang, X. B.

AU - Wu, Q. K.

AU - Li, F. P.

AU - Hu, X. Y.

AU - Lu, B. J.

AU - Yang, Z. Y.

AU - Zhang, M. X.

AU - Shi, W. B.

AU - He, Q.

AU - Li, Y.

AU - Jiang, K. P.

AU - Xue, J. D.

AU - Li, X. D.

AU - Jiang, J. M.

AU - Lu, W.

AU - Tian, G. J.

AU - Hu, Z. B.

AU - Guo, J. C.

AU - Li, C. Z.

AU - Deng, X.

AU - Luo, X. L.

AU - Li, F. Y.

AU - Zhang, X. W.

AU - Zheng, Y. J.

AU - Zhao, G.

AU - Wang, L. C.

AU - Wu, J. H.

AU - Guo, H.

AU - Mi, Y. Q.

AU - Gong, Z. J.

AU - Wang, C. B.

AU - Jiang, F.

AU - Guo, P.

AU - Yang, X. Z.

AU - Shi, W. Q.

AU - Yang, H. Z.

AU - Zhou, Y.

AU - Sun, N. N.

AU - Jiao, Y. T.

AU - Gao, Y. Q.

AU - Zhou, D. Q.

AU - Ye, Y. A.

PY - 2018/9

Y1 - 2018/9

N2 - The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n = 596), and HBeAg-negative chronic hepatitis B (n = 611). HBsAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HBsAg titres varied significantly in different phases (P =.000), with the highest (4.60 log10 IU/mL [10%-90% confidence interval: 3.52 log10 IU/mL-4.99 log10 IU/mL]) in patients with HBeAg-positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HBsAg level. In HBeAg-positive chronic hepatitis B patients, a negative correlation between HBsAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HBsAg titres in HBeAg-negative chronic hepatitis B patients. In conclusion, decreased HBsAg titres may be associated with advancing fibrosis in HBeAg-positive chronic hepatitis B patients or increased necroinflammation in those with HBeAg-negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HBsAg and provide useful insights into the management of this disease.

AB - The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n = 596), and HBeAg-negative chronic hepatitis B (n = 611). HBsAg titres in the different phases were compared, and multiple linear progression analyses were performed to investigate the implicated factors. HBsAg titres varied significantly in different phases (P =.000), with the highest (4.60 log10 IU/mL [10%-90% confidence interval: 3.52 log10 IU/mL-4.99 log10 IU/mL]) in patients with HBeAg-positive chronic HBV infection. In all phases, age and HBV DNA were correlated with serum HBsAg level. In HBeAg-positive chronic hepatitis B patients, a negative correlation between HBsAg titres and fibrosis stage was observed. Alanine amonitransferase or necroinflammatory activity was also correlated with HBsAg titres in HBeAg-negative chronic hepatitis B patients. In conclusion, decreased HBsAg titres may be associated with advancing fibrosis in HBeAg-positive chronic hepatitis B patients or increased necroinflammation in those with HBeAg-negative chronic hepatitis B. Our findings may help clinicians better understand the kinetics of HBsAg and provide useful insights into the management of this disease.

KW - Adult

KW - Alanine Transaminase/blood

KW - China

KW - DNA, Viral/blood

KW - Female

KW - Hepatitis B Surface Antigens/blood

KW - Hepatitis B e Antigens/blood

KW - Hepatitis B, Chronic/complications

KW - Humans

KW - Liver Cirrhosis/pathology

KW - Male

KW - Middle Aged

KW - Serum/chemistry

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85046798948&partnerID=8YFLogxK

U2 - 10.1111/jvh.12903

DO - 10.1111/jvh.12903

M3 - Article

C2 - 29624802

AN - SCOPUS:85046798948

SN - 1352-0504

VL - 25

SP - 1017

EP - 1025

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

IS - 9

ER -

Serum hepatitis B surface antigen correlates with fibrosis and necroinflammation: A multicentre perspective in China

Abstract

Keywords

UN SDGs

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