Sensing cellular stress through STIM proteins

Jonathan Soboloff; Muniswamy Madesh; Donald L. Gill

doi:10.1038/nchembio.619

Sensing cellular stress through STIM proteins

Jonathan Soboloff, Muniswamy Madesh, Donald L. Gill

Temple University

Research output: Contribution to journal › Comment/debate

38 Scopus citations

Abstract

In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.

Original language	English
Pages (from-to)	488-492
Number of pages	5
Journal	Nature Chemical Biology
Volume	7
Issue number	8
DOIs	https://doi.org/10.1038/nchembio.619
State	Published - Aug 2011

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title = "Sensing cellular stress through STIM proteins",

abstract = "In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.",

author = "Jonathan Soboloff and Muniswamy Madesh and Gill, {Donald L.}",

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AU - Madesh, Muniswamy

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AB - In response to decreasing Ca2+ levels in the endoplasmic reticulum, STIM proteins couple with Orai channels in the plasma membrane, leading to Ca2+ influx into the cell. In addition to Ca2+-related endoplasmic reticulum stress, STIM proteins are emerging as general stress sensors that react to multiple stress signals to orchestrate Ca2+ signaling and homeostasis.

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U2 - 10.1038/nchembio.619

DO - 10.1038/nchembio.619

M3 - Comment/debate

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SN - 1552-4450

VL - 7

SP - 488

EP - 492

JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 8

ER -

Sensing cellular stress through STIM proteins

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