Senescence Inflames the Pancreatic Tumor Microenvironment

Giulia Petroni; Lorenzo Galluzzi

doi:10.1016/j.xcrm.2020.100020

Senescence Inflames the Pancreatic Tumor Microenvironment

Giulia Petroni, Lorenzo Galluzzi

Research output: Contribution to journal › Comment/debate

6 Scopus citations

Abstract

Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators¹ have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8⁺ T cells.

Original language	English
Article number	100020
Journal	Cell Reports Medicine
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/j.xcrm.2020.100020
State	Published - May 19 2020
Externally published	Yes

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title = "Senescence Inflames the Pancreatic Tumor Microenvironment",

abstract = "Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators1 have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8+ T cells.",

author = "Giulia Petroni and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = may,

day = "19",

doi = "10.1016/j.xcrm.2020.100020",

language = "English",

volume = "1",

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TY - JOUR

T1 - Senescence Inflames the Pancreatic Tumor Microenvironment

AU - Petroni, Giulia

AU - Galluzzi, Lorenzo

PY - 2020/5/19

Y1 - 2020/5/19

N2 - Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators1 have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8+ T cells.

AB - Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of Cell, Lowe and collaborators1 have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8+ T cells.

UR - http://www.scopus.com/inward/record.url?scp=85109031161&partnerID=8YFLogxK

U2 - 10.1016/j.xcrm.2020.100020

DO - 10.1016/j.xcrm.2020.100020

M3 - Comment/debate

C2 - 33205059

AN - SCOPUS:85109031161

SN - 2666-3791

VL - 1

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 2

M1 - 100020

ER -

Senescence Inflames the Pancreatic Tumor Microenvironment

Abstract

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