Secondary Necrosis: Accidental No More

Lorenzo Galluzzi; Guido Kroemer

doi:10.1016/j.trecan.2016.12.001

Secondary Necrosis: Accidental No More

Lorenzo Galluzzi, Guido Kroemer

Research output: Contribution to journal › Short survey › peer-review

27 Scopus citations

Abstract

Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.

Original language	English
Pages (from-to)	1-2
Number of pages	2
Journal	Trends in Cancer
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/j.trecan.2016.12.001
State	Published - Jan 1 2017
Externally published	Yes

Keywords

caspases
danger signaling
DFNA5
GSDMD
necroptosis
pyroptosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.trecan.2016.12.001

Cite this

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title = "Secondary Necrosis: Accidental No More",

abstract = "Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.",

keywords = "caspases, danger signaling, DFNA5, GSDMD, necroptosis, pyroptosis",

author = "Lorenzo Galluzzi and Guido Kroemer",

note = "Publisher Copyright: {\textcopyright} 2016",

year = "2017",

month = jan,

day = "1",

doi = "10.1016/j.trecan.2016.12.001",

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T1 - Secondary Necrosis

T2 - Accidental No More

AU - Galluzzi, Lorenzo

AU - Kroemer, Guido

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.

AB - Recent data demonstrate that secondary necrosis is not an accidental epiphenomenon of apoptosis, but a finely regulated process with prominent pathophysiological and therapeutic implications. The molecular machinery that controls secondary necrosis stands out as a promising target for the development of novel drugs that may increase the immunogenicity of cancer cells succumbing to treatment.

KW - caspases

KW - danger signaling

KW - DFNA5

KW - GSDMD

KW - necroptosis

KW - pyroptosis

UR - http://www.scopus.com/inward/record.url?scp=85008516021&partnerID=8YFLogxK

U2 - 10.1016/j.trecan.2016.12.001

DO - 10.1016/j.trecan.2016.12.001

M3 - Short survey

C2 - 28718422

AN - SCOPUS:85008516021

SN - 2405-8033

VL - 3

SP - 1

EP - 2

JO - Trends in Cancer

JF - Trends in Cancer

IS - 1

ER -

Secondary Necrosis: Accidental No More

Abstract

Keywords

UN SDGs

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