Abstract
Objective: To evaluate the role of second-look laparotomy following platinum-based chemotherapy in patients with fallopian tube cancer. Methods: We conducted a retrospective chart review of 35 patients with tubal cancer who underwent a second-look laparotomy following cytoreductive surgery and platinum-based combination chemotherapy. Results: The distribution by stage was as follows: I, three (9%); II, five (14%); III, 24 (69%); and IV, two (6%); one patient was inadequately staged. The tumor grade was recorded in 31 patients, and 80% of these were grade 2 or 3. Twenty-one of the 35 patients (60%) were found to be free of disease at second-look operation. Neither stage nor grade were predictive of findings at the second-look procedure, although none of the five patients with stage I disease and/or grade 1 tumor had disease found at second-look surgery. The absence of gross residual disease following primary surgery was the strongest predictor of disease-free status at second-look laparotomy (P < .01). With a mean follow-up of 50 months among the survivors, only four (19%) of the patients with no evidence of tumor at reexploration have had a recurrence. Conclusion: Second-look laparotomy provides useful prognostic information in patients with tubal cancer; approximately 80% of patients who have a negative second-look following platinum-based chemotherapy will remain disease-free. (Obstet Gynecol 1993;82:748-51).
Original language | English |
---|---|
Pages (from-to) | 748-751 |
Number of pages | 4 |
Journal | Obstetrics and Gynecology |
Volume | 82 |
Issue number | 5 |
State | Published - Nov 1993 |
Keywords
- Actuarial Analysis
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols/therapeutic use
- Combined Modality Therapy
- Fallopian Tube Neoplasms/diagnosis
- Female
- Follow-Up Studies
- Humans
- Laparotomy
- Middle Aged
- Neoplasm Metastasis
- Neoplasm Staging
- Reoperation
- Retrospective Studies
- Survival Rate