TY - JOUR
T1 - Screening for ovarian cancer in the general population
AU - Chu, Christina S.
AU - Rubin, Stephen C.
PY - 2006/4
Y1 - 2006/4
N2 - Screening for ovarian cancer in the general population presents several unique challenges. Without a clearly identified premalignant state, efforts have focused on detection of early stage disease. Towards this end, investigators have focused on the use of serum markers and transvaginal ultrasound. CA125 determination is the most reliable serum marker in use, and utilization of serial measurements to calculate risk of cancer appears to have greater utility than evaluation of a single value. Multimodality screening focuses on combining serial CA125 measurement with transvaginal ultrasound follow-up for those with abnormal values. Large prospective trials, such as the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), are currently underway to assess the impact of various screening strategies on mortality, and to evaluate feasibility, acceptability, and morbidity of screening. Future research efforts will undoubtedly focus on promising techniques to examine the serum proteosome for patterns to identify early ovarian cancer.
AB - Screening for ovarian cancer in the general population presents several unique challenges. Without a clearly identified premalignant state, efforts have focused on detection of early stage disease. Towards this end, investigators have focused on the use of serum markers and transvaginal ultrasound. CA125 determination is the most reliable serum marker in use, and utilization of serial measurements to calculate risk of cancer appears to have greater utility than evaluation of a single value. Multimodality screening focuses on combining serial CA125 measurement with transvaginal ultrasound follow-up for those with abnormal values. Large prospective trials, such as the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), are currently underway to assess the impact of various screening strategies on mortality, and to evaluate feasibility, acceptability, and morbidity of screening. Future research efforts will undoubtedly focus on promising techniques to examine the serum proteosome for patterns to identify early ovarian cancer.
KW - CA-125
KW - Ovarian cancer
KW - Population surveillance
KW - Proteomics
KW - Screening
KW - Ultrasonography
UR - http://www.scopus.com/inward/record.url?scp=33644893064&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000236611100008&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.bpobgyn.2005.10.012
DO - 10.1016/j.bpobgyn.2005.10.012
M3 - Review article
C2 - 16364690
SN - 1521-6934
VL - 20
SP - 307
EP - 320
JO - Best Practice and Research in Clinical Obstetrics and Gynaecology
JF - Best Practice and Research in Clinical Obstetrics and Gynaecology
IS - 2
ER -
