TY - JOUR
T1 - Screen-detected adenocarcinoma of the lung. Practical points for surgical pathologists.
AU - Flieder, Douglas B.
PY - 2003/6
Y1 - 2003/6
N2 - Recent technological advances in thoracic radiology and surgery have altered the types of lung specimens handled by cytologists and surgical pathologists. Increasing numbers of individuals with small peripheral adenocarcinomas undergo minimally invasive diagnostic procedures and, in some instances, minimally invasive surgical procedures. The pathologist's role in early lung adenocarcinoma research is central, as clinical and investigational studies depend more than ever on subtle pathologic distinctions. Establishing a diagnosis of malignant neoplasm on samples from fine-needle aspiration, core biopsy, or frozen section is fraught with new considerations, and surgically resected adenocarcinomas must be typed according to the recently revised World Health Organization classification. Familiarity with small glandular proliferations, including the putative precursor lesion atypical adenomatous hyperplasia, will prevent misdiagnoses and untoward impact on tumor staging, therapy, and outcome studies.
AB - Recent technological advances in thoracic radiology and surgery have altered the types of lung specimens handled by cytologists and surgical pathologists. Increasing numbers of individuals with small peripheral adenocarcinomas undergo minimally invasive diagnostic procedures and, in some instances, minimally invasive surgical procedures. The pathologist's role in early lung adenocarcinoma research is central, as clinical and investigational studies depend more than ever on subtle pathologic distinctions. Establishing a diagnosis of malignant neoplasm on samples from fine-needle aspiration, core biopsy, or frozen section is fraught with new considerations, and surgically resected adenocarcinomas must be typed according to the recently revised World Health Organization classification. Familiarity with small glandular proliferations, including the putative precursor lesion atypical adenomatous hyperplasia, will prevent misdiagnoses and untoward impact on tumor staging, therapy, and outcome studies.
KW - Adenocarcinoma/classification
KW - Humans
KW - Lung Neoplasms/classification
KW - Mass Screening
KW - Pathology, Surgical/methods
UR - http://www.scopus.com/inward/record.url?scp=0042283824&partnerID=8YFLogxK
U2 - 10.1309/D736-X3HG-DX1W-00TN
DO - 10.1309/D736-X3HG-DX1W-00TN
M3 - Review article
C2 - 12951843
AN - SCOPUS:0042283824
SN - 0002-9173
VL - 119 Suppl
SP - S39-57
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
ER -