ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome

Zihan Chen; Zaihua Cheng; Congcong Ding; Tianyu Cao; Ling Chen; Hong Wang; Junpei Li; Xiao Huang

doi:10.1007/s10557-023-07531-3

ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome

Zihan Chen
, Zaihua Cheng
, Congcong Ding
, Tianyu Cao
, Ling Chen
, Hong Wang
, Junpei Li
, Xiao Huang

Nuclear Dynamics and Cancer (NDC)

Nanchang University
University of California at Santa Barbara
the First People’s Hospital of Jiujiang
Temple University

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

The transient receptor potential melastatin 2 (TRPM2) channel is a nonselective calcium channel that is sensitive to oxidative stress (OS), and is widely expressed in multiple organs, such as the heart, kidney, and brain, which is inextricably related to calcium dyshomeostasis and downstream pathological events. Due to the increasing global burden of kidney or cardiovascular diseases (CVDs), safe and efficient drugs specific to novel targets are imperatively needed. Notably, investigation of the possibility to regard the TRPM2 channel as a new therapeutic target in ROS-related CVDs or renal diseases is urgently required because the roles of the TRPM2 channel in heart or kidney diseases have not received enough attention and thus have not been fully elaborated. Therefore, we aimed to review the involvement of the TRPM2 channel in cardiovascular disorders related to kidney or typical renal diseases and attempted to speculate about TRPM2-mediated mechanisms of cardiorenal syndrome (CRS) to provide representative perspectives for future research about novel and effective therapeutic strategies.

Original language	English
Pages (from-to)	615-631
Number of pages	17
Journal	Cardiovascular Drugs and Therapy
Volume	39
Issue number	3
Early online date	Nov 18 2023
DOIs	https://doi.org/10.1007/s10557-023-07531-3
State	Published - Jun 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Calcium Signaling/drug effects
Calcium/metabolism
Cardio-Renal Syndrome/metabolism
Cardiovascular System/metabolism
Homeostasis
Humans
Kidney/metabolism
Oxidative Stress
Reactive Oxygen Species/metabolism
TRPM Cation Channels/metabolism

Access to Document

10.1007/s10557-023-07531-3

Cite this

@article{52ab10a64a7941baa0287c5351387f06,

title = "ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome",

abstract = "The transient receptor potential melastatin 2 (TRPM2) channel is a nonselective calcium channel that is sensitive to oxidative stress (OS), and is widely expressed in multiple organs, such as the heart, kidney, and brain, which is inextricably related to calcium dyshomeostasis and downstream pathological events. Due to the increasing global burden of kidney or cardiovascular diseases (CVDs), safe and efficient drugs specific to novel targets are imperatively needed. Notably, investigation of the possibility to regard the TRPM2 channel as a new therapeutic target in ROS-related CVDs or renal diseases is urgently required because the roles of the TRPM2 channel in heart or kidney diseases have not received enough attention and thus have not been fully elaborated. Therefore, we aimed to review the involvement of the TRPM2 channel in cardiovascular disorders related to kidney or typical renal diseases and attempted to speculate about TRPM2-mediated mechanisms of cardiorenal syndrome (CRS) to provide representative perspectives for future research about novel and effective therapeutic strategies.",

keywords = "Animals, Calcium Signaling/drug effects, Calcium/metabolism, Cardio-Renal Syndrome/metabolism, Cardiovascular System/metabolism, Homeostasis, Humans, Kidney/metabolism, Oxidative Stress, Reactive Oxygen Species/metabolism, TRPM Cation Channels/metabolism",

author = "Zihan Chen and Zaihua Cheng and Congcong Ding and Tianyu Cao and Ling Chen and Hong Wang and Junpei Li and Xiao Huang",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.",

year = "2025",

month = jun,

doi = "10.1007/s10557-023-07531-3",

language = "English",

volume = "39",

pages = "615--631",

journal = "Cardiovascular Drugs and Therapy",

issn = "0920-3206",

publisher = "Springer",

number = "3",

}

TY - JOUR

T1 - ROS-Activated TRPM2 Channel

T2 - Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome

AU - Chen, Zihan

AU - Cheng, Zaihua

AU - Ding, Congcong

AU - Cao, Tianyu

AU - Chen, Ling

AU - Wang, Hong

AU - Li, Junpei

AU - Huang, Xiao

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023.

PY - 2025/6

Y1 - 2025/6

N2 - The transient receptor potential melastatin 2 (TRPM2) channel is a nonselective calcium channel that is sensitive to oxidative stress (OS), and is widely expressed in multiple organs, such as the heart, kidney, and brain, which is inextricably related to calcium dyshomeostasis and downstream pathological events. Due to the increasing global burden of kidney or cardiovascular diseases (CVDs), safe and efficient drugs specific to novel targets are imperatively needed. Notably, investigation of the possibility to regard the TRPM2 channel as a new therapeutic target in ROS-related CVDs or renal diseases is urgently required because the roles of the TRPM2 channel in heart or kidney diseases have not received enough attention and thus have not been fully elaborated. Therefore, we aimed to review the involvement of the TRPM2 channel in cardiovascular disorders related to kidney or typical renal diseases and attempted to speculate about TRPM2-mediated mechanisms of cardiorenal syndrome (CRS) to provide representative perspectives for future research about novel and effective therapeutic strategies.

AB - The transient receptor potential melastatin 2 (TRPM2) channel is a nonselective calcium channel that is sensitive to oxidative stress (OS), and is widely expressed in multiple organs, such as the heart, kidney, and brain, which is inextricably related to calcium dyshomeostasis and downstream pathological events. Due to the increasing global burden of kidney or cardiovascular diseases (CVDs), safe and efficient drugs specific to novel targets are imperatively needed. Notably, investigation of the possibility to regard the TRPM2 channel as a new therapeutic target in ROS-related CVDs or renal diseases is urgently required because the roles of the TRPM2 channel in heart or kidney diseases have not received enough attention and thus have not been fully elaborated. Therefore, we aimed to review the involvement of the TRPM2 channel in cardiovascular disorders related to kidney or typical renal diseases and attempted to speculate about TRPM2-mediated mechanisms of cardiorenal syndrome (CRS) to provide representative perspectives for future research about novel and effective therapeutic strategies.

KW - Animals

KW - Calcium Signaling/drug effects

KW - Calcium/metabolism

KW - Cardio-Renal Syndrome/metabolism

KW - Cardiovascular System/metabolism

KW - Homeostasis

KW - Humans

KW - Kidney/metabolism

KW - Oxidative Stress

KW - Reactive Oxygen Species/metabolism

KW - TRPM Cation Channels/metabolism

UR - https://www.scopus.com/pages/publications/85180257213

U2 - 10.1007/s10557-023-07531-3

DO - 10.1007/s10557-023-07531-3

M3 - Review article

C2 - 38108918

AN - SCOPUS:85180257213

SN - 0920-3206

VL - 39

SP - 615

EP - 631

JO - Cardiovascular Drugs and Therapy

JF - Cardiovascular Drugs and Therapy

IS - 3

ER -

ROS-Activated TRPM2 Channel: Calcium Homeostasis in Cardiovascular/renal System and Speculation in Cardiorenal Syndrome

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this