RNF2 E3 or not to E3: Dual roles of RNF2 overexpression in melanoma

Joshua C. Black; Johnathan R. Whetstine

doi:10.1158/2159-8290.CD-15-1285

RNF2 E3 or not to E3: Dual roles of RNF2 overexpression in melanoma

Joshua C. Black, Johnathan R. Whetstine

Harvard University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

RNF2/RING1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity; however, the biologic importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically independent and catalytically dependent processes.

Original language	English
Pages (from-to)	1241-1243
Number of pages	3
Journal	Cancer Discovery
Volume	5
Issue number	12
DOIs	https://doi.org/10.1158/2159-8290.CD-15-1285
State	Published - Dec 2015

Keywords

Humans
Melanoma
Polycomb Repressive Complex 1
Ubiquitin-Protein Ligases

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10.1158/2159-8290.CD-15-1285

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abstract = "RNF2/RING1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity; however, the biologic importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically independent and catalytically dependent processes.",

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RNF2 E3 or not to E3: Dual roles of RNF2 overexpression in melanoma

Abstract

Keywords

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