RNF2 E3 or not to E3: Dual roles of RNF2 overexpression in melanoma

Joshua C. Black, Johnathan R. Whetstine

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

RNF2/RING1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity; however, the biologic importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically independent and catalytically dependent processes.

Original languageEnglish
Pages (from-to)1241-1243
Number of pages3
JournalCancer Discovery
Volume5
Issue number12
DOIs
StatePublished - Dec 2015
Externally publishedYes

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