RNA repair: Damage control

Alfonso Bellacosa; Eric G. Moss

doi:10.1016/S0960-9822(03)00408-1

RNA repair: Damage control

Alfonso Bellacosa
, Eric G. Moss

Fox Chase Cancer Center

Research output: Contribution to journal › Short survey › peer-review

73 Scopus citations

Abstract

RNA in a cell is subject to many of the same insults as DNA. RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress.

Original language	English
Pages (from-to)	R482-R484
Journal	Current Biology
Volume	13
Issue number	12
DOIs	https://doi.org/10.1016/S0960-9822(03)00408-1
State	Published - Jun 17 2003

Keywords

Alkylation
Animals
Apoptosis/physiology
DNA Damage/physiology
DNA Repair/physiology
Drug-Related Side Effects and Adverse Reactions
Humans
RNA Stability/physiology
RNA/physiology

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10.1016/S0960-9822(03)00408-1

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title = "RNA repair: Damage control",

abstract = "RNA in a cell is subject to many of the same insults as DNA. RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress.",

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T2 - Damage control

AU - Bellacosa, Alfonso

AU - Moss, Eric G.

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AB - RNA in a cell is subject to many of the same insults as DNA. RNA damage can induce apoptosis and may be exploited for anti-cancer chemotherapy. It is a surprise, however, to learn that cells may repair RNA damage, suggesting a far greater significance of RNA in genotoxic stress.

KW - Alkylation

KW - Animals

KW - Apoptosis/physiology

KW - DNA Damage/physiology

KW - DNA Repair/physiology

KW - Drug-Related Side Effects and Adverse Reactions

KW - Humans

KW - RNA Stability/physiology

KW - RNA/physiology

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DO - 10.1016/S0960-9822(03)00408-1

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SP - R482-R484

JO - Current Biology

JF - Current Biology

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ER -

RNA repair: Damage control

Abstract

Keywords

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