RIP kinases initiate programmed necrosis

Lorenzo Galluzzi; Oliver Kepp; Guido Kroemer

doi:10.1093/jmcb/mjp007

RIP kinases initiate programmed necrosis

Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer

Cancer Signaling and Microenvironment (CSM)

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Journal of Molecular Cell Biology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1093/jmcb/mjp007
State	Published - Oct 2009

Keywords

Animals
Apoptosis
Membrane Potential, Mitochondrial
Mice
Mitochondria/enzymology
Necrosis/enzymology
Reactive Oxygen Species/metabolism
Receptor-Interacting Protein Serine-Threonine Kinases/metabolism

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10.1093/jmcb/mjp007

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abstract = "Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.",

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author = "Lorenzo Galluzzi and Oliver Kepp and Guido Kroemer",

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AU - Kepp, Oliver

AU - Kroemer, Guido

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AB - Some lethal stimuli can induce either apoptosis or necrosis, depending on the cell type and/or experimental setting. Until recently, the molecular bases of this phenomenon were largely unknown. Now, two members of the receptor-interacting serine-threonine kinase (RIP) family, RIP1 and RIP3, have been demonstrated to control the switch between apoptotic and necrotic cell death. Some mechanistic details, however, remain controversial.

KW - Animals

KW - Apoptosis

KW - Membrane Potential, Mitochondrial

KW - Mice

KW - Mitochondria/enzymology

KW - Necrosis/enzymology

KW - Reactive Oxygen Species/metabolism

KW - Receptor-Interacting Protein Serine-Threonine Kinases/metabolism

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DO - 10.1093/jmcb/mjp007

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JO - Journal of Molecular Cell Biology

JF - Journal of Molecular Cell Biology

IS - 1

ER -

RIP kinases initiate programmed necrosis

Abstract

Keywords

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