Rho-GTPases: New members, new pathways

Elena M. Sorokina; Jonathan Chernoff

doi:10.1002/jcb.20327

Rho-GTPases: New members, new pathways

Elena M. Sorokina, Jonathan Chernoff

Cancer Signaling and Microenvironment (CSM)

Fox Chase Cancer Center

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Proteins comprising the Rho family of GTPases mediate reorganization of the actin cytoskeleton as well as transcription of genes. Recent findings from genome sequencing efforts, genetic screens, and signal transduction research have revealed that the Rho family contains several new, hitherto unrecognized members. In this review, we focus on these newly discovered Rho-GTPases and discuss their role in signaling to the cytoskeleton and the nucleus.

Original language	English
Pages (from-to)	225-231
Number of pages	7
Journal	Journal of Cellular Biochemistry
Volume	94
Issue number	2
DOIs	https://doi.org/10.1002/jcb.20327
State	Published - Feb 1 2005

Keywords

Cdc42
Cytoskeleton
Effectors
GTPases
Rac
Rho
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10.1002/jcb.20327

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AB - Proteins comprising the Rho family of GTPases mediate reorganization of the actin cytoskeleton as well as transcription of genes. Recent findings from genome sequencing efforts, genetic screens, and signal transduction research have revealed that the Rho family contains several new, hitherto unrecognized members. In this review, we focus on these newly discovered Rho-GTPases and discuss their role in signaling to the cytoskeleton and the nucleus.

KW - Cdc42

KW - Cytoskeleton

KW - Effectors

KW - GTPases

KW - Rac

KW - Rho

KW - Transcription

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Rho-GTPases: New members, new pathways

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Keywords

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