Rho-GTPases: New members, new pathways

Elena M. Sorokina, Jonathan Chernoff

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Proteins comprising the Rho family of GTPases mediate reorganization of the actin cytoskeleton as well as transcription of genes. Recent findings from genome sequencing efforts, genetic screens, and signal transduction research have revealed that the Rho family contains several new, hitherto unrecognized members. In this review, we focus on these newly discovered Rho-GTPases and discuss their role in signaling to the cytoskeleton and the nucleus.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalJournal of Cellular Biochemistry
Issue number2
StatePublished - Feb 1 2005


  • Cdc42
  • Cytoskeleton
  • Effectors
  • GTPases
  • Rac
  • Rho
  • Transcription


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