Reproductive Profile of Neuronal Androgen Receptor Knockout Female Mice With a Low Dose of DHT

Vaibhave Ubba, Serene Joseph, Olubusayo Awe, Dustin Jones, Milan K Dsilva, Mingxiao Feng, Junjiang Wang, Xiaomin Fu, Razeen J Akbar, Brittany H Bodnar, Wenhui Hu, Hong Wang, Xiaofeng Yang, Ling Yang, Peixin Yang, Bouchra Taib, Rexford Ahima, Sara Divall, Sheng Wu

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperandrogenism and polycystic ovarian syndrome result from the imbalance or increase of androgen levels in females. Androgen receptor (AR) mediates the effects of androgens, and this study examines whether neuronal AR plays a role in reproduction under normal and increased androgen conditions in female mice. The neuron-specific AR knockout (KO) mouse (SynARKO) was generated from a female mouse (synapsin promoter driven Cre) and a male mouse (Ar fl/y). Puberty onset and the levels of reproductive hormones such as LH, FSH, testosterone, and estradiol were comparable between the control and the SynARKO mice. There were no differences in cyclicity and fertility between the control and SynARKO mice, with similar impairment in both groups on DHT treatment. Neuronal AR KO, as in this SynARKO mouse model, did not alleviate the infertility associated with DHT treatment. These studies suggest that neuronal AR KO neither altered reproductive function under physiological androgen levels, nor restored fertility under hyperandrogenic conditions.

Original languageEnglish
Article numberbqad199
JournalEndocrinology
Volume165
Issue number3
DOIs
StatePublished - Mar 1 2024

Keywords

  • Humans
  • Female
  • Male
  • Mice
  • Animals
  • Androgens/pharmacology
  • Receptors, Androgen/genetics
  • Mice, Knockout
  • Sexual Maturation
  • Polycystic Ovary Syndrome
  • Reproduction/genetics
  • Neurons

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