Repair of chromatinized DNA

N. S. Gerasimova; N. A. Pestov; O. I. Kulaeva; D. V. Nikitin; M. P. Kirpichnikov; V. M. Studitsky

doi:10.3103/S0096392515030050

Repair of chromatinized DNA

N. S. Gerasimova, N. A. Pestov, O. I. Kulaeva, D. V. Nikitin, M. P. Kirpichnikov, V. M. Studitsky

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Endogenous and exogenous agents generate tens of thousands of lesions in the DNA of every cell daily. The maintenance of correct DNA structure by repair systems is crucial for genome functioning. Eukaryotic nuclear DNA is tightly packaged into chromatin, in which it should be successfully repaired. Historically, it is believed that histones are temporarily removed from the repaired DNA. However, numerous recent studies indicate that the chromatin structure affects the repair response, limiting its distribution, altering enzyme activity, and participating in the response choice and restoration of the repaired locus function.

Original language	English
Pages (from-to)	122-126
Number of pages	5
Journal	Moscow University Biological Sciences Bulletin
Volume	70
Issue number	3
DOIs	https://doi.org/10.3103/S0096392515030050
State	Published - Jul 29 2015
Externally published	Yes

Keywords

DNA
DNA breaks
RNA polymerase II
chromatin
histone
nucleosome
oxidative stress
repair
review

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10.3103/S0096392515030050

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title = "Repair of chromatinized DNA",

abstract = "Endogenous and exogenous agents generate tens of thousands of lesions in the DNA of every cell daily. The maintenance of correct DNA structure by repair systems is crucial for genome functioning. Eukaryotic nuclear DNA is tightly packaged into chromatin, in which it should be successfully repaired. Historically, it is believed that histones are temporarily removed from the repaired DNA. However, numerous recent studies indicate that the chromatin structure affects the repair response, limiting its distribution, altering enzyme activity, and participating in the response choice and restoration of the repaired locus function.",

keywords = "DNA, DNA breaks, RNA polymerase II, chromatin, histone, nucleosome, oxidative stress, repair, review",

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AU - Gerasimova, N. S.

AU - Pestov, N. A.

AU - Kulaeva, O. I.

AU - Nikitin, D. V.

AU - Kirpichnikov, M. P.

AU - Studitsky, V. M.

PY - 2015/7/29

Y1 - 2015/7/29

N2 - Endogenous and exogenous agents generate tens of thousands of lesions in the DNA of every cell daily. The maintenance of correct DNA structure by repair systems is crucial for genome functioning. Eukaryotic nuclear DNA is tightly packaged into chromatin, in which it should be successfully repaired. Historically, it is believed that histones are temporarily removed from the repaired DNA. However, numerous recent studies indicate that the chromatin structure affects the repair response, limiting its distribution, altering enzyme activity, and participating in the response choice and restoration of the repaired locus function.

AB - Endogenous and exogenous agents generate tens of thousands of lesions in the DNA of every cell daily. The maintenance of correct DNA structure by repair systems is crucial for genome functioning. Eukaryotic nuclear DNA is tightly packaged into chromatin, in which it should be successfully repaired. Historically, it is believed that histones are temporarily removed from the repaired DNA. However, numerous recent studies indicate that the chromatin structure affects the repair response, limiting its distribution, altering enzyme activity, and participating in the response choice and restoration of the repaired locus function.

KW - DNA

KW - DNA breaks

KW - RNA polymerase II

KW - chromatin

KW - histone

KW - nucleosome

KW - oxidative stress

KW - repair

KW - review

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M3 - Article

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VL - 70

SP - 122

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JO - Moscow University Biological Sciences Bulletin

JF - Moscow University Biological Sciences Bulletin

IS - 3

ER -

Repair of chromatinized DNA

Abstract

Keywords

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