Abstract
Objective: To determine the distribution of saliva CA 125 levels in women with and without ovarian cancer, and to determine whether there is a correlation between saliva and serum CA 125 levels in either group. Methods: CA 125 levels were measured by immunoradiometric assay in the serum and saliva of 50 women with epithelial ovarian cancer known to have elevated serum CA 125 levels (above 35 U/mL) and in 50 women seen for benign gynecologic conditions. Results: Serum and saliva CA 125 values followed a log-normal distribution in both groups. The medians for serum and saliva CA 125 levels in cancer patients were 578 and 1379 U/mL, respectively. In the benign group, the median CA 125 value was 11 U/mL in serum and 994 U/mL in saliva. The correlation between saliva and serum CA 125 levels was not statistically significant in either the cancer (r = 0.003) or the benign group (r = 0.025). Conclusion: There is no relationship between saliva and serum CA 125 levels in women with either epithelial ovarian cancer or benign gynecologic conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 989-992 |
| Number of pages | 4 |
| Journal | Obstetrics and Gynecology |
| Volume | 81 |
| Issue number | 6 |
| State | Published - Jun 1993 |
Keywords
- Antigens, Tumor-Associated, Carbohydrate/analysis
- Female
- Genital Diseases, Female/diagnosis
- Humans
- Immunoradiometric Assay
- Middle Aged
- Ovarian Neoplasms/diagnosis
- Prospective Studies
- Saliva/immunology
