Abstract
Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.
| Original language | English |
|---|---|
| Pages (from-to) | 710-716 |
| Number of pages | 7 |
| Journal | Current Opinion in Pharmacology |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antineoplastic Agents/pharmacology
- Cell Membrane/metabolism
- Cholesterol/biosynthesis
- Humans
- Lipid Metabolism
- Lipids/biosynthesis
- Neoplasms/drug therapy
- Signal Transduction
- Sterols/metabolism
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