Regulation of cholesterol biosynthesis and cancer signaling

Andrey Gorin; Linara Gabitova; Igor Astsaturov

doi:10.1016/j.coph.2012.06.011

Regulation of cholesterol biosynthesis and cancer signaling

Andrey Gorin, Linara Gabitova, Igor Astsaturov

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Abstract

Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.

Original language	English
Pages (from-to)	710-716
Number of pages	7
Journal	Current Opinion in Pharmacology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.coph.2012.06.011
State	Published - Dec 2012

Keywords

Antineoplastic Agents/pharmacology
Cell Membrane/metabolism
Cholesterol/biosynthesis
Humans
Lipid Metabolism
Lipids/biosynthesis
Neoplasms/drug therapy
Signal Transduction
Sterols/metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coph.2012.06.011

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title = "Regulation of cholesterol biosynthesis and cancer signaling",

abstract = "Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.",

keywords = "Antineoplastic Agents/pharmacology, Cell Membrane/metabolism, Cholesterol/biosynthesis, Humans, Lipid Metabolism, Lipids/biosynthesis, Neoplasms/drug therapy, Signal Transduction, Sterols/metabolism",

author = "Andrey Gorin and Linara Gabitova and Igor Astsaturov",

year = "2012",

month = dec,

doi = "10.1016/j.coph.2012.06.011",

language = "English",

volume = "12",

pages = "710--716",

journal = "Current Opinion in Pharmacology",

issn = "1471-4892",

publisher = "Elsevier Ltd.",

number = "6",

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TY - JOUR

T1 - Regulation of cholesterol biosynthesis and cancer signaling

AU - Gorin, Andrey

AU - Gabitova, Linara

AU - Astsaturov, Igor

PY - 2012/12

Y1 - 2012/12

N2 - Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.

AB - Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.

KW - Antineoplastic Agents/pharmacology

KW - Cell Membrane/metabolism

KW - Cholesterol/biosynthesis

KW - Humans

KW - Lipid Metabolism

KW - Lipids/biosynthesis

KW - Neoplasms/drug therapy

KW - Signal Transduction

KW - Sterols/metabolism

UR - http://www.scopus.com/inward/record.url?scp=84870542378&partnerID=8YFLogxK

U2 - 10.1016/j.coph.2012.06.011

DO - 10.1016/j.coph.2012.06.011

M3 - Review article

C2 - 22824431

SN - 1471-4892

VL - 12

SP - 710

EP - 716

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

IS - 6

ER -

Regulation of cholesterol biosynthesis and cancer signaling

Abstract

Keywords

UN SDGs

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