Regulation of cholesterol biosynthesis and cancer signaling

Andrey Gorin, Linara Gabitova, Igor Astsaturov

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Cellular growth is highly dependent on sustained production of lipids. Sterol composition of cellular membranes determines multiple biochemical and biophysical properties of membrane-based processes including vesicle traffic, receptor signaling, and assembly of protein complexes. Lipid biogenesis has become an attractive biochemical target in cancer given the high level of dependency on sterols and lipids in a cancer cell. This review summarized the current knowledge of mechanisms of interaction between the metabolism of sterols and receptor signaling.

Original languageEnglish
Pages (from-to)710-716
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume12
Issue number6
DOIs
StatePublished - Dec 2012

Keywords

  • Antineoplastic Agents/pharmacology
  • Cell Membrane/metabolism
  • Cholesterol/biosynthesis
  • Humans
  • Lipid Metabolism
  • Lipids/biosynthesis
  • Neoplasms/drug therapy
  • Signal Transduction
  • Sterols/metabolism

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