Real-time treatment light dose guidance of Pleural PDT: An update

Timothy C. Zhu, Michele M. Kim, Steven L. Jacques, Rozhin Penjweini, Andreea Dimofte, Jarod C. Finlay, Charles B. Simone, Keith A. Cengel, Joseph Friedberg

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

11 Scopus citations

Abstract

The goal of this study was to develop and improve an infrared (IR) navigation system to deliver light dose uniformly during intracavitory PDT by tracking the movement of the light source and providing real-time feedback on the light fluence rate on the entire cavity surface area. In the current intrapleural PDT protocol, several detectors placed in selected locations in the pleural cavity monitor the light doses. To improve the delivery of light dose uniformity, an IR camera system is used to track the motion of the light source as well as the surface contour of the pleural cavity. Monte-Carlo simulation is used to improve the calculation algorithm for the effect of light that undergoes multiple scattering along the surface in addition to an improvement of the direct light calculation using an improved model that accounts for the anisotropy of the light from the light source.

Original languageEnglish
Title of host publicationOptical Methods for Tumor Treatment and Detection
Subtitle of host publicationMechanisms and Techniques in Photodynamic Therapy XXIV
EditorsDavid H. Kessel, Tayyaba Hasan
PublisherSPIE
Volume9308
ISBN (Electronic)9781628413984
DOIs
StatePublished - 2015
EventOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV - San Francisco, United States
Duration: Feb 7 2015Feb 9 2015

Publication series

NameProceedings of SPIE--the International Society for Optical Engineering
ISSN (Print)0277-786X

Conference

ConferenceOptical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIV
Country/TerritoryUnited States
CitySan Francisco
Period02/7/1502/9/15

Keywords

  • intra-cavitary treatment planning
  • light dosimetry
  • light fluence
  • MC simulation
  • Photodynamic therapy

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