Re-engineering the functions of a terminally differentiated epithelial cell in vivo

Bruce J. Baum; Songlin Wang; Edna Cukierman; Christine Delporte; Hideaki Kagami; Yitzhak Marmary; Fox Philip C; David J. Mooney; Kenneth M. Yamada

doi:10.1111/j.1749-6632.1999.tb08512.x

Re-engineering the functions of a terminally differentiated epithelial cell in vivo

Bruce J. Baum, Songlin Wang, Edna Cukierman, Christine Delporte, Hideaki Kagami, Yitzhak Marmary, Fox Philip C, David J. Mooney, Kenneth M. Yamada

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Because of their easy access, and important role in oral homeostasis, mammalian salivary glands provide a unique site for addressing key issues and problems in tissue engineering. This manuscript reviews studies by us in three major directions involving re-engineering functions of salivary epithelial cells. Using adenoviral-mediated gene transfer in vivo, we show approaches to i) repair damaged, hypofunctional glands and ii) redesign secretory functions to include endocrine as well as exocrine pathways. The third series of studies show our general approach to develop an artificial salivary gland for clinical situations in which all glandular tissue has been lost.

Original language	English
Pages (from-to)	294-300
Number of pages	7
Journal	Annals of the New York Academy of Sciences
Volume	875
DOIs	https://doi.org/10.1111/j.1749-6632.1999.tb08512.x
State	Published - 1999

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abstract = "Because of their easy access, and important role in oral homeostasis, mammalian salivary glands provide a unique site for addressing key issues and problems in tissue engineering. This manuscript reviews studies by us in three major directions involving re-engineering functions of salivary epithelial cells. Using adenoviral-mediated gene transfer in vivo, we show approaches to i) repair damaged, hypofunctional glands and ii) redesign secretory functions to include endocrine as well as exocrine pathways. The third series of studies show our general approach to develop an artificial salivary gland for clinical situations in which all glandular tissue has been lost.",

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AU - Baum, Bruce J.

AU - Wang, Songlin

AU - Cukierman, Edna

AU - Delporte, Christine

AU - Kagami, Hideaki

AU - Marmary, Yitzhak

AU - Philip C, Fox

AU - Mooney, David J.

AU - Yamada, Kenneth M.

PY - 1999

Y1 - 1999

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AB - Because of their easy access, and important role in oral homeostasis, mammalian salivary glands provide a unique site for addressing key issues and problems in tissue engineering. This manuscript reviews studies by us in three major directions involving re-engineering functions of salivary epithelial cells. Using adenoviral-mediated gene transfer in vivo, we show approaches to i) repair damaged, hypofunctional glands and ii) redesign secretory functions to include endocrine as well as exocrine pathways. The third series of studies show our general approach to develop an artificial salivary gland for clinical situations in which all glandular tissue has been lost.

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JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Re-engineering the functions of a terminally differentiated epithelial cell in vivo

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