Rapid progression of prostate cancer in men with a BRCA2 mutation

S. A. Narod; S. Neuhausen; G. Vichodez; S. Armel; H. T. Lynch; P. Ghadirian; S. Cummings; O. Olopade; D. Stoppa-Lyonnet; F. Couch; T. Wagner; E. Warner; W. D. Foulkes; H. Saal; J. Weitzel; A. Tulman; A. Poll; R. Nam; P. Sun; Jessica Danquah; Susan Domchek; Nadine Tung; Peter Ainsworth; Douglas Horsman; Charmaine Kim-Sing; Christine Maugard; Andrea Eisen; Mary Daly; Wendy McKinnon; Marie Wood; Claudine Isaacs; Dawna Gilchrist; Beth Karlan; Raluca Nedelcu; Wendy Meschino; Judy Garber; Barbara Pasini; Siranoush Manoukian; Christina Bellati

doi:10.1038/sj.bjc.6604453

Rapid progression of prostate cancer in men with a BRCA2 mutation

S. A. Narod, S. Neuhausen, G. Vichodez, S. Armel, H. T. Lynch, P. Ghadirian, S. Cummings, O. Olopade, D. Stoppa-Lyonnet, F. Couch, T. Wagner, E. Warner, W. D. Foulkes, H. Saal, J. Weitzel, A. Tulman, A. Poll, R. Nam, P. Sun, Jessica DanquahSusan Domchek, Nadine Tung, Peter Ainsworth, Douglas Horsman, Charmaine Kim-Sing, Christine Maugard, Andrea Eisen, Mary Daly, Wendy McKinnon, Marie Wood, Claudine Isaacs, Dawna Gilchrist, Beth Karlan, Raluca Nedelcu, Wendy Meschino, Judy Garber, Barbara Pasini, Siranoush Manoukian, Christina Bellati

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

Original language	English
Pages (from-to)	371-374
Number of pages	4
Journal	British Journal of Cancer
Volume	99
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6604453
State	Published - Jun 22 2008

Keywords

Adult
Aged
Aged, 80 and over
Disease Progression
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Heterozygote
Humans
Male
Middle Aged
Mutation
Prostatic Neoplasms/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6604453

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Narod, S. A., Neuhausen, S., Vichodez, G., Armel, S., Lynch, H. T., Ghadirian, P., Cummings, S., Olopade, O., Stoppa-Lyonnet, D., Couch, F., Wagner, T., Warner, E., Foulkes, W. D., Saal, H., Weitzel, J., Tulman, A., Poll, A., Nam, R., Sun, P., ... Bellati, C. (2008). Rapid progression of prostate cancer in men with a BRCA2 mutation. British Journal of Cancer, 99(2), 371-374. https://doi.org/10.1038/sj.bjc.6604453

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title = "Rapid progression of prostate cancer in men with a BRCA2 mutation",

abstract = "Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.",

keywords = "Adult, Aged, Aged, 80 and over, Disease Progression, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Heterozygote, Humans, Male, Middle Aged, Mutation, Prostatic Neoplasms/genetics",

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Narod, SA, Neuhausen, S, Vichodez, G, Armel, S, Lynch, HT, Ghadirian, P, Cummings, S, Olopade, O, Stoppa-Lyonnet, D, Couch, F, Wagner, T, Warner, E, Foulkes, WD, Saal, H, Weitzel, J, Tulman, A, Poll, A, Nam, R, Sun, P, Danquah, J, Domchek, S, Tung, N, Ainsworth, P, Horsman, D, Kim-Sing, C, Maugard, C, Eisen, A, Daly, M, McKinnon, W, Wood, M, Isaacs, C, Gilchrist, D, Karlan, B, Nedelcu, R, Meschino, W, Garber, J, Pasini, B, Manoukian, S & Bellati, C 2008, 'Rapid progression of prostate cancer in men with a BRCA2 mutation', British Journal of Cancer, vol. 99, no. 2, pp. 371-374. https://doi.org/10.1038/sj.bjc.6604453

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AU - Narod, S. A.

AU - Neuhausen, S.

AU - Vichodez, G.

AU - Armel, S.

AU - Lynch, H. T.

AU - Ghadirian, P.

AU - Cummings, S.

AU - Olopade, O.

AU - Stoppa-Lyonnet, D.

AU - Couch, F.

AU - Wagner, T.

AU - Warner, E.

AU - Foulkes, W. D.

AU - Saal, H.

AU - Weitzel, J.

AU - Tulman, A.

AU - Poll, A.

AU - Nam, R.

AU - Sun, P.

AU - Danquah, Jessica

AU - Domchek, Susan

AU - Tung, Nadine

AU - Ainsworth, Peter

AU - Horsman, Douglas

AU - Kim-Sing, Charmaine

AU - Maugard, Christine

AU - Eisen, Andrea

AU - Daly, Mary

AU - McKinnon, Wendy

AU - Wood, Marie

AU - Isaacs, Claudine

AU - Gilchrist, Dawna

AU - Karlan, Beth

AU - Nedelcu, Raluca

AU - Meschino, Wendy

AU - Garber, Judy

AU - Pasini, Barbara

AU - Manoukian, Siranoush

AU - Bellati, Christina

PY - 2008/6/22

Y1 - 2008/6/22

N2 - Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

AB - Men with BRCA2 mutations have been found to be at increased risk of developing prostate cancer. There is a recent report that BRCA2 carriers with prostate cancer have poorer survival than noncarrier prostate cancer patients. In this study, we compared survival of men with a BRCA2 mutation and prostate cancer with that of men with a BRCA1 mutation and prostate cancer. We obtained the age at diagnosis, age at death or current age from 182 men with prostate cancer from families with a BRCA2 mutation and from 119 men with prostate cancer from families with a BRCA1 mutation. The median survival from diagnosis was 4.0 years for men with a BRCA2 mutation vs 8.0 years for men with a BRCA1 mutation, and the difference was highly significant (P<0.01). It may be important to develop targeted chemotherapies to treat prostate cancer in men with a BRCA2 mutation.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Disease Progression

KW - Genes, BRCA1

KW - Genes, BRCA2

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Humans

KW - Male

KW - Middle Aged

KW - Mutation

KW - Prostatic Neoplasms/genetics

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U2 - 10.1038/sj.bjc.6604453

DO - 10.1038/sj.bjc.6604453

M3 - Article

C2 - 18577985

AN - SCOPUS:48249136563

SN - 0007-0920

VL - 99

SP - 371

EP - 374

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 2

ER -

Rapid progression of prostate cancer in men with a BRCA2 mutation

Abstract

Keywords

UN SDGs

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