Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

Eric C. Ko; Lorenzo Galluzzi

doi:10.1080/2162402X.2019.1606624

Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

Eric C. Ko, Lorenzo Galluzzi

Research output: Contribution to journal › Editorial

2 Scopus citations

Abstract

CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.

Original language	English
Article number	e1606624
Journal	Oncoimmunology
Volume	8
Issue number	8
DOIs	https://doi.org/10.1080/2162402X.2019.1606624
State	Published - 2019
Externally published	Yes

Keywords

CGAS
ipilimumab
non-small cell lung carcinoma
STING
TREX1
type I interferon

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402X.2019.1606624

Cite this

@article{5e450354100e43ffaea2f24bdd3500a3,

title = "Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients",

abstract = "CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.",

keywords = "CGAS, ipilimumab, non-small cell lung carcinoma, STING, TREX1, type I interferon",

author = "Ko, \{Eric C.\} and Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Taylor \& Francis Group, LLC.",

year = "2019",

doi = "10.1080/2162402X.2019.1606624",

language = "English",

volume = "8",

journal = "Oncoimmunology",

issn = "2162-4011",

publisher = "Taylor and Francis Ltd.",

number = "8",

}

TY - JOUR

T1 - Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

AU - Ko, Eric C.

AU - Galluzzi, Lorenzo

PY - 2019

Y1 - 2019

N2 - CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.

AB - CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with increased circulating levels of type I interferon and dynamic changes in the peripheral T cell repertoire.

KW - CGAS

KW - ipilimumab

KW - non-small cell lung carcinoma

KW - STING

KW - TREX1

KW - type I interferon

UR - https://www.scopus.com/pages/publications/85064747693

U2 - 10.1080/2162402X.2019.1606624

DO - 10.1080/2162402X.2019.1606624

M3 - Editorial

C2 - 31413913

AN - SCOPUS:85064747693

SN - 2162-4011

VL - 8

JO - Oncoimmunology

JF - Oncoimmunology

IS - 8

M1 - e1606624

ER -

Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

Abstract

Keywords

UN SDGs

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