Radiation Therapy Toxicity to the Skin

T. J. FitzGerald; Maryann Bishop Jodoin; Gayle Tillman; Jesse Aronowitz; Richard Pieters; Susan Balducci; Joshua Meyer; M. Giulia Cicchetti; Sidney Kadish; Shelagh McCauley; Joanna Sawicka; Marcia Urie; Y. C. Lo; Charles Mayo; Kenneth Ulin; Linda Ding; Maureen Britton; Jiayi Huang; Edward Arous

doi:10.1016/j.det.2007.08.005

Radiation Therapy Toxicity to the Skin

T. J. FitzGerald, Maryann Bishop Jodoin, Gayle Tillman, Jesse Aronowitz, Richard Pieters, Susan Balducci, Joshua Meyer, M. Giulia Cicchetti, Sidney Kadish, Shelagh McCauley, Joanna Sawicka, Marcia Urie, Y. C. Lo, Charles Mayo, Kenneth Ulin, Linda Ding, Maureen Britton, Jiayi Huang, Edward Arous

University of Massachusetts Medical School

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

Radiation therapy has been integral to cancer patient care. The skin is an intentional and unintentional target of therapy, and is sensitive to the volume of normal tissue in the radiation therapy treatment field, daily treatment dose (fractionation), and total treatment dose. We must understand the relationship of these factors to patient outcome as we move toward hypofractionation treatment strategies (radiosurgery). Chemotherapy agents and prescription medications may influence therapy-associated sequelae. Understanding this may prevent significant injury and discomfort. This article reviews established platforms of radiation therapy and sequelae associated with skin therapy. Interactions with other agents and possible predisposition to sequelae are reviewed. Skin cancer resulting from treatment and disease processes associated with possible limited outcome are also reviewed.

Original language	English
Pages (from-to)	161-172
Number of pages	12
Journal	Dermatologic Clinics
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/j.det.2007.08.005
State	Published - Jan 2008

Keywords

Antineoplastic Agents/adverse effects
Humans
Neoplasms/radiotherapy
Radiotherapy/adverse effects
Skin Care
Skin Neoplasms/secondary
Skin/drug effects

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10.1016/j.det.2007.08.005

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FitzGerald, T. J., Jodoin, M. B., Tillman, G., Aronowitz, J., Pieters, R., Balducci, S., Meyer, J., Cicchetti, M. G., Kadish, S., McCauley, S., Sawicka, J., Urie, M., Lo, Y. C., Mayo, C., Ulin, K., Ding, L., Britton, M., Huang, J., & Arous, E. (2008). Radiation Therapy Toxicity to the Skin. Dermatologic Clinics, 26(1), 161-172. https://doi.org/10.1016/j.det.2007.08.005

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abstract = "Radiation therapy has been integral to cancer patient care. The skin is an intentional and unintentional target of therapy, and is sensitive to the volume of normal tissue in the radiation therapy treatment field, daily treatment dose (fractionation), and total treatment dose. We must understand the relationship of these factors to patient outcome as we move toward hypofractionation treatment strategies (radiosurgery). Chemotherapy agents and prescription medications may influence therapy-associated sequelae. Understanding this may prevent significant injury and discomfort. This article reviews established platforms of radiation therapy and sequelae associated with skin therapy. Interactions with other agents and possible predisposition to sequelae are reviewed. Skin cancer resulting from treatment and disease processes associated with possible limited outcome are also reviewed.",

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AU - FitzGerald, T. J.

AU - Jodoin, Maryann Bishop

AU - Tillman, Gayle

AU - Aronowitz, Jesse

AU - Pieters, Richard

AU - Balducci, Susan

AU - Meyer, Joshua

AU - Cicchetti, M. Giulia

AU - Kadish, Sidney

AU - McCauley, Shelagh

AU - Sawicka, Joanna

AU - Urie, Marcia

AU - Lo, Y. C.

AU - Mayo, Charles

AU - Ulin, Kenneth

AU - Ding, Linda

AU - Britton, Maureen

AU - Huang, Jiayi

AU - Arous, Edward

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AB - Radiation therapy has been integral to cancer patient care. The skin is an intentional and unintentional target of therapy, and is sensitive to the volume of normal tissue in the radiation therapy treatment field, daily treatment dose (fractionation), and total treatment dose. We must understand the relationship of these factors to patient outcome as we move toward hypofractionation treatment strategies (radiosurgery). Chemotherapy agents and prescription medications may influence therapy-associated sequelae. Understanding this may prevent significant injury and discomfort. This article reviews established platforms of radiation therapy and sequelae associated with skin therapy. Interactions with other agents and possible predisposition to sequelae are reviewed. Skin cancer resulting from treatment and disease processes associated with possible limited outcome are also reviewed.

KW - Antineoplastic Agents/adverse effects

KW - Humans

KW - Neoplasms/radiotherapy

KW - Radiotherapy/adverse effects

KW - Skin Care

KW - Skin Neoplasms/secondary

KW - Skin/drug effects

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DO - 10.1016/j.det.2007.08.005

M3 - Review article

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VL - 26

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EP - 172

JO - Dermatologic Clinics

JF - Dermatologic Clinics

IS - 1

ER -

Radiation Therapy Toxicity to the Skin

Abstract

Keywords

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