Radiation therapy as a biological modifier of the breast cancer immune microenvironment

Lorenzo Galluzzi; Lukas Bolini; Rebecca M. Shulman

doi:10.1038/s41523-025-00801-3

Radiation therapy as a biological modifier of the breast cancer immune microenvironment

Fox Chase Cancer Center

Research output: Contribution to journal › Comment/debate

Abstract

Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.

Original language	English
Article number	84
Journal	npj Breast Cancer
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41523-025-00801-3
State	Published - Aug 1 2025

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SDG 3 Good Health and Well-being

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10.1038/s41523-025-00801-3

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title = "Radiation therapy as a biological modifier of the breast cancer immune microenvironment",

abstract = "Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.",

author = "Lorenzo Galluzzi and Lukas Bolini and Shulman, \{Rebecca M.\}",

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T1 - Radiation therapy as a biological modifier of the breast cancer immune microenvironment

AU - Galluzzi, Lorenzo

AU - Bolini, Lukas

AU - Shulman, Rebecca M.

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/8/1

Y1 - 2025/8/1

N2 - Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.

AB - Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.

UR - https://www.scopus.com/pages/publications/105012404826

U2 - 10.1038/s41523-025-00801-3

DO - 10.1038/s41523-025-00801-3

M3 - Comment/debate

C2 - 40750605

AN - SCOPUS:105012404826

SN - 2374-4677

VL - 11

JO - npj Breast Cancer

JF - npj Breast Cancer

IS - 1

M1 - 84

ER -

Radiation therapy as a biological modifier of the breast cancer immune microenvironment

Abstract

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