Abstract
E-cadherin is a cell adhesion molecule that is present in most normal epithelial cells. During malignant transformation, the expression of E-cadherin is frequently repressed. This protein is considered as a tumor-suppressor. The oncogenic form of Akt, a serine-threonine kinase, is multifunctionnal. One of its function is to induce the transcriptional repression of E-cadherin. This transcriptional repression induces cellular responses, epithelial cells becoming mesenchymal and invasive. At the molecular level, cells expressing a constitutive active form of Akt express also a transcription factor, Snail, known to repress the expression of E-cadherin.
| Translated title of the contribution | Regulation of E-cadherin by the Akt protein kinase B |
|---|---|
| Original language | French |
| Pages (from-to) | 375-378 |
| Number of pages | 4 |
| Journal | Journal de la Societe de Biologie |
| Volume | 198 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2004 |
Keywords
- Animals
- Cadherins/genetics
- Gene Expression Regulation/physiology
- Humans
- Models, Biological
- Phosphorylation
- Protein Serine-Threonine Kinases/metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins/metabolism
- Vimentin/physiology