Pyroptosis - A cell death modality of its kind?

Oliver Kepp, Lorenzo Galluzzi, Laurence Zitvogel, Guido Kroemer

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations

Abstract

The term "pyroptosis" was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis - which can also be triggered by nonbacterial pathological stimuli - truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.

Original languageEnglish
Pages (from-to)627-630
Number of pages4
JournalEuropean Journal of Immunology
Volume40
Issue number3
DOIs
StatePublished - Mar 2010
Externally publishedYes

Keywords

  • Apoptosis
  • Inflammation
  • Macrophages

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