PTP1B: A double agent in metabolism and oncogenesis

Shu Chin Yip, Sayanti Saha, Jonathan Chernoff

Research output: Contribution to journalReview articlepeer-review

230 Scopus citations


PTP1B, a non-transmembrane protein tyrosine phosphatase that has long been studied as a negative regulator of insulin and leptin signaling, has received renewed attention as an unexpected positive factor in tumorigenesis. Here, we highlight how views of this enzyme have evolved from regarding it as a simple metabolic off-switch to a more complex view of PTP1B as an enzyme that can play both negative and positive roles in diverse signaling pathways. These dual characteristics make PTP1B a particularly attractive therapeutic target for diabetes, obesity, and perhaps breast cancer.

Original languageEnglish
Pages (from-to)442-449
Number of pages8
JournalTrends in Biochemical Sciences
Issue number8
StatePublished - Aug 2010


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