TY - JOUR
T1 - Psychological reactivity to laboratory stress is associated with hormonal responses in postmenopausal women
AU - Fang, Carolyn Y.
AU - Egleston, Brian L.
AU - Manzur, Angelica M.
AU - Townsend, Raymond R.
AU - Stanczyk, Frank Z.
AU - Spiegel, David
AU - Dorgan, Joanne F.
PY - 2014/3
Y1 - 2014/3
N2 - Objective: The present study examined associations between psychological reactivity and hormonal responses to a standardized laboratory stressor (Trier Social Stress Test, TSST) in postmenopausal women. Methods: Postmenopausal women aged 50-74 years undertook anxiety and mood assessments prior to and following the TSST. Blood samples were drawn at multiple timepoints for assessment of cortisol, adrenocorticotrophic hormone (ACTH) and dehydroepiandrosterone (DHEA). Results: Forty postmenopausal women completed the assessments. As expected, significant increases in anxiety and negative affect and decreases in positive affect were observed after the TSST; however, the magnitude of change in anxiety and mood varied considerably across individuals. Analyses indicated that greater increases in anxiety and negative affect after the TSST were associated with higher levels of cortisol, ACTH and DHEA after controlling for race, age, body mass index and smoking status. Changes in positive affect were not associated with cortisol, ACTH or DHEA. Conclusions: These findings suggest that enhanced reactivity to stress is associated with higher hormone levels among postmenopausal women, which could have potential implications for health.
AB - Objective: The present study examined associations between psychological reactivity and hormonal responses to a standardized laboratory stressor (Trier Social Stress Test, TSST) in postmenopausal women. Methods: Postmenopausal women aged 50-74 years undertook anxiety and mood assessments prior to and following the TSST. Blood samples were drawn at multiple timepoints for assessment of cortisol, adrenocorticotrophic hormone (ACTH) and dehydroepiandrosterone (DHEA). Results: Forty postmenopausal women completed the assessments. As expected, significant increases in anxiety and negative affect and decreases in positive affect were observed after the TSST; however, the magnitude of change in anxiety and mood varied considerably across individuals. Analyses indicated that greater increases in anxiety and negative affect after the TSST were associated with higher levels of cortisol, ACTH and DHEA after controlling for race, age, body mass index and smoking status. Changes in positive affect were not associated with cortisol, ACTH or DHEA. Conclusions: These findings suggest that enhanced reactivity to stress is associated with higher hormone levels among postmenopausal women, which could have potential implications for health.
KW - Trier Social Stress Test
KW - adrenocorticotrophic hormone
KW - anxiety
KW - cortisol
KW - dehydroepiandrosterone
KW - negative affect
UR - http://www.scopus.com/inward/record.url?scp=84898680126&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000333007000021&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1177/0300060513504696
DO - 10.1177/0300060513504696
M3 - Article
C2 - 24595153
SN - 0300-0605
VL - 42
SP - 444
EP - 456
JO - Journal of International Medical Research
JF - Journal of International Medical Research
IS - 2
ER -