Propionyl-CoA metabolism links chromatin acylation to cardiac transcription

Christina Demetriadou; Andrew A. Gibb; John W. Elrod; Nathaniel W. Snyder

doi:10.1038/s44161-023-00381-0

Propionyl-CoA metabolism links chromatin acylation to cardiac transcription

Christina Demetriadou
, Andrew A. Gibb
, John W. Elrod
, Nathaniel W. Snyder

Cancer Signaling and Microenvironment (CSM)

University of Pennsylvania
Temple University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

Original language	English
Pages (from-to)	1109-1111
Number of pages	3
Journal	Nature Cardiovascular Research
Volume	2
Issue number	12
DOIs	https://doi.org/10.1038/s44161-023-00381-0
State	Published - Dec 2023

Keywords

Acyl Coenzyme A/metabolism
Acylation
Animals
Chromatin/metabolism
Epigenesis, Genetic
Mice
Myocardium/metabolism
Oxidation-Reduction
Propionic Acidemia/metabolism
Transcription, Genetic

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10.1038/s44161-023-00381-0

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title = "Propionyl-CoA metabolism links chromatin acylation to cardiac transcription",

abstract = "The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.",

keywords = "Acyl Coenzyme A/metabolism, Acylation, Animals, Chromatin/metabolism, Epigenesis, Genetic, Mice, Myocardium/metabolism, Oxidation-Reduction, Propionic Acidemia/metabolism, Transcription, Genetic",

author = "Christina Demetriadou and Gibb, \{Andrew A.\} and Elrod, \{John W.\} and Snyder, \{Nathaniel W.\}",

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AU - Demetriadou, Christina

AU - Gibb, Andrew A.

AU - Elrod, John W.

AU - Snyder, Nathaniel W.

PY - 2023/12

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N2 - The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

AB - The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

KW - Acyl Coenzyme A/metabolism

KW - Acylation

KW - Animals

KW - Chromatin/metabolism

KW - Epigenesis, Genetic

KW - Mice

KW - Myocardium/metabolism

KW - Oxidation-Reduction

KW - Propionic Acidemia/metabolism

KW - Transcription, Genetic

UR - https://www.scopus.com/pages/publications/85178488799

U2 - 10.1038/s44161-023-00381-0

DO - 10.1038/s44161-023-00381-0

M3 - Article

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AN - SCOPUS:85178488799

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SP - 1109

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JO - Nature Cardiovascular Research

JF - Nature Cardiovascular Research

IS - 12

ER -

Propionyl-CoA metabolism links chromatin acylation to cardiac transcription

Abstract

Keywords

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