TY - JOUR
T1 - Propionyl-CoA metabolism links chromatin acylation to cardiac transcription
AU - Demetriadou, Christina
AU - Gibb, Andrew A.
AU - Elrod, John W.
AU - Snyder, Nathaniel W.
PY - 2023/12
Y1 - 2023/12
N2 - The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.
AB - The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.
KW - Acyl Coenzyme A/metabolism
KW - Acylation
KW - Animals
KW - Chromatin/metabolism
KW - Epigenesis, Genetic
KW - Mice
KW - Myocardium/metabolism
KW - Oxidation-Reduction
KW - Propionic Acidemia/metabolism
KW - Transcription, Genetic
UR - http://www.scopus.com/inward/record.url?scp=85178488799&partnerID=8YFLogxK
U2 - 10.1038/s44161-023-00381-0
DO - 10.1038/s44161-023-00381-0
M3 - Article
C2 - 39188987
AN - SCOPUS:85178488799
SN - 2731-0590
VL - 2
SP - 1109
EP - 1111
JO - Nature Cardiovascular Research
JF - Nature Cardiovascular Research
IS - 12
ER -