Propionyl-CoA metabolism links chromatin acylation to cardiac transcription

Christina Demetriadou, Andrew A. Gibb, John W. Elrod, Nathaniel W. Snyder

Research output: Contribution to journalArticlepeer-review

Abstract

The molecular mechanisms that link propionyl-CoA metabolism and epigenetic regulation of gene expression are unclear, as are the implications for heart function. Now, new insights into the modulation of chromatin acylation and transcription by aberrant oxidation of propionyl-CoA are revealed in the dysfunctional hearts of mice with propionic acidemia.

Original languageEnglish
Pages (from-to)1109-1111
Number of pages3
JournalNature Cardiovascular Research
Volume2
Issue number12
DOIs
StatePublished - Dec 2023

Keywords

  • Acyl Coenzyme A/metabolism
  • Acylation
  • Animals
  • Chromatin/metabolism
  • Epigenesis, Genetic
  • Mice
  • Myocardium/metabolism
  • Oxidation-Reduction
  • Propionic Acidemia/metabolism
  • Transcription, Genetic

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