Prophylactic Cranial Irradiation for Small-Cell Lung Cancer: Time for a Reassessment.

Martin Edelman

doi:10.1200/edbk_281041

Prophylactic Cranial Irradiation for Small-Cell Lung Cancer: Time for a Reassessment.

Research output: Contribution to journal › Article › peer-review

Abstract

Prophylactic cranial irradiation (PCI) has been an accepted part of the management of both limited and small-cell lung cancer; however, the data that support its use in limited-stage disease is based on an analysis of trials done before currently accepted approaches to staging (i.e., brain MRI and/or PET scanning) were available. For extensive disease, data are available from two randomized studies that are in direct conflict. This article explores the basic rationale for PCI and the evidence indicating that it is time to readdress the question of its routine use.

Original language	Undefined/Unknown
Pages (from-to)	24-28
Number of pages	4
Journal	American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
Volume	40
DOIs	https://doi.org/10.1200/edbk_281041
State	Published - May 1 2020

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10.1200/edbk_281041

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abstract = "Prophylactic cranial irradiation (PCI) has been an accepted part of the management of both limited and small-cell lung cancer; however, the data that support its use in limited-stage disease is based on an analysis of trials done before currently accepted approaches to staging (i.e., brain MRI and/or PET scanning) were available. For extensive disease, data are available from two randomized studies that are in direct conflict. This article explores the basic rationale for PCI and the evidence indicating that it is time to readdress the question of its routine use.",

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AB - Prophylactic cranial irradiation (PCI) has been an accepted part of the management of both limited and small-cell lung cancer; however, the data that support its use in limited-stage disease is based on an analysis of trials done before currently accepted approaches to staging (i.e., brain MRI and/or PET scanning) were available. For extensive disease, data are available from two randomized studies that are in direct conflict. This article explores the basic rationale for PCI and the evidence indicating that it is time to readdress the question of its routine use.

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JO - American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

JF - American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

ER -

Prophylactic Cranial Irradiation for Small-Cell Lung Cancer: Time for a Reassessment.

Abstract

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