Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation

Donna E. Hogge; Shinichi Misawa; Charles A. Schiffer; Joseph R. Testa

doi:10.1016/0145-2126(84)90056-0

Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation

Donna E. Hogge
, Shinichi Misawa
, Charles A. Schiffer
, Joseph R. Testa

Cancer Prevention and Control (CPC)

University of Maryland Cancer Center

Research output: Contribution to journal › Editorial

40 Scopus citations

Abstract

A patient with Philadelphia chromosome Ph¹-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph¹-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.

Original language	English
Pages (from-to)	1019-1023
Number of pages	5
Journal	Leukemia Research
Volume	8
Issue number	6
DOIs	https://doi.org/10.1016/0145-2126(84)90056-0
State	Published - 1984

Keywords

Adult
Chromosomes, Human, 13-15
Chromosomes, Human, 16-18
Humans
Leukemia, Myeloid, Acute/genetics
Leukemia, Myeloid/genetics
Male
Translocation, Genetic

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title = "Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation",

abstract = "A patient with Philadelphia chromosome Ph1-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph1-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.",

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author = "Hogge, \{Donna E.\} and Shinichi Misawa and Schiffer, \{Charles A.\} and Testa, \{Joseph R.\}",

year = "1984",

doi = "10.1016/0145-2126(84)90056-0",

language = "English",

volume = "8",

pages = "1019--1023",

journal = "Leukemia Research",

issn = "0145-2126",

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TY - JOUR

T1 - Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation

AU - Hogge, Donna E.

AU - Misawa, Shinichi

AU - Schiffer, Charles A.

AU - Testa, Joseph R.

PY - 1984

Y1 - 1984

N2 - A patient with Philadelphia chromosome Ph1-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph1-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.

AB - A patient with Philadelphia chromosome Ph1-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph1-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.

KW - Adult

KW - Chromosomes, Human, 13-15

KW - Chromosomes, Human, 16-18

KW - Humans

KW - Leukemia, Myeloid, Acute/genetics

KW - Leukemia, Myeloid/genetics

KW - Male

KW - Translocation, Genetic

UR - https://www.scopus.com/pages/publications/0021707160

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U2 - 10.1016/0145-2126(84)90056-0

DO - 10.1016/0145-2126(84)90056-0

M3 - Editorial

C2 - 6595476

SN - 0145-2126

VL - 8

SP - 1019

EP - 1023

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation

Abstract

Keywords

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