Promyelocytic blast crisis in chronic granulocytic leukemia with 15;17 translocation

Donna E. Hogge, Shinichi Misawa, Charles A. Schiffer, Joseph R. Testa

Research output: Contribution to journalEditorial

37 Scopus citations


A patient with Philadelphia chromosome Ph1-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph1-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.

Original languageEnglish
Pages (from-to)1019-1023
Number of pages5
JournalLeukemia Research
Issue number6
StatePublished - 1984


  • Adult
  • Chromosomes, Human, 13-15
  • Chromosomes, Human, 16-18
  • Humans
  • Leukemia, Myeloid, Acute/genetics
  • Leukemia, Myeloid/genetics
  • Male
  • Translocation, Genetic


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