Abstract
A patient with Philadelphia chromosome Ph1-positive chronic granulocytic leukemia (CGL) developed an acute transformation associated with a hemorrhagic diathesis and bone marrow infiltration by hypergranular promyelocytes and blasts. Cytogenetic analysis of bone marrow metaphase cells at transformation showed a t(15;17) superimposed upon the Ph1-positive cell line. These findings suggest a critical relationship between the t(15;17) and arrest of myeloid leukemic cell differentiation at the promyelocyte stage.
Original language | English |
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Pages (from-to) | 1019-1023 |
Number of pages | 5 |
Journal | Leukemia Research |
Volume | 8 |
Issue number | 6 |
DOIs | |
State | Published - 1984 |
Keywords
- Adult
- Chromosomes, Human, 13-15
- Chromosomes, Human, 16-18
- Humans
- Leukemia, Myeloid, Acute/genetics
- Leukemia, Myeloid/genetics
- Male
- Translocation, Genetic