Abstract
We describe a patient with a CD8+/CD4- primary cutaneous CD30(+) lymphoproliferative disorder with striking epidermotropic histology and coincident cutaneous and systemic sarcoidosis. This patient illustrates the spectrum of clinical and histologic features of CD30+ lymphoproliferative disorders and the need for adequate staging in such cases. This patient's CD30/CD8 coexpression is rare and has clinical and prognostic implications, including mucosally and acrally accentuated lesions and a potentially more aggressive course. Primary cutaneous CD30+ lymphoproliferative disorders have an excellent prognosis; therefore multiagent chemotherapy modalities are generally not indicated. The combination of T-cell lymphoma and sarcoidosis is also rare and may limit treatment options.
Original language | English |
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Pages (from-to) | 304-308 |
Number of pages | 5 |
Journal | Journal of the American Academy of Dermatology |
Volume | 51 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2004 |
Keywords
- Adult
- Biopsy
- CD4-CD8 Ratio
- Humans
- Ki-1 Antigen/analysis
- Lymphoma, T-Cell, Cutaneous/immunology
- Male
- Sarcoidosis/complications