Progressive epidermotropic CD8+/CD4- primary cutaneous CD30+ lymphoproliferative disorder in a patient with sarcoidosis.

Joel M. Gelfand, Mariusz A. Wasik, Carmela Vittorio, Alain Rook, Jacqueline M. Junkins-Hopkins

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We describe a patient with a CD8+/CD4- primary cutaneous CD30(+) lymphoproliferative disorder with striking epidermotropic histology and coincident cutaneous and systemic sarcoidosis. This patient illustrates the spectrum of clinical and histologic features of CD30+ lymphoproliferative disorders and the need for adequate staging in such cases. This patient's CD30/CD8 coexpression is rare and has clinical and prognostic implications, including mucosally and acrally accentuated lesions and a potentially more aggressive course. Primary cutaneous CD30+ lymphoproliferative disorders have an excellent prognosis; therefore multiagent chemotherapy modalities are generally not indicated. The combination of T-cell lymphoma and sarcoidosis is also rare and may limit treatment options.

Original languageEnglish
Pages (from-to)304-308
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume51
Issue number2
DOIs
StatePublished - Aug 2004

Keywords

  • Adult
  • Biopsy
  • CD4-CD8 Ratio
  • Humans
  • Ki-1 Antigen/analysis
  • Lymphoma, T-Cell, Cutaneous/immunology
  • Male
  • Sarcoidosis/complications

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