Abstract
Primary central nervous system lymphoma (PCNSL) is an uncommon subtype of extra-nodal lymphomas arising in and confined to the brain, eyes, spinal cord, and leptomeninges. This chapter focuses on B-cell PCNSL. Combining whole-brain radiation therapy (WBRT) with High-dose methotrexate (HDMTX) improves disease control and perhaps survivals. High-dose chemotherapy (HDT) followed by autologous hematopoietic cell transplant (auto-HCT) is emerging as an effective consolidation treatments for patients with PCNSL. It is reasonable to consider autologous hematopoietic cell transplant (auto-HCT) for selected patients with chemosensitive relapsed or refractory PCNSL. Patients with HIV associated Hodgkin and non-Hodgkin lymphoma have similar transplant outcomes when compared with non-HIV patients. HDMTX with leucovorin rescue is the single most effective treatment for PCNSL. Monotherapy HDMTX and HDMTX based combination chemotherapy yielded similar efficacy, but the former requires more frequent dose reductions because of impaired creatinine clearance.
| Original language | English |
|---|---|
| Title of host publication | Clinical Manual of Blood and Bone Marrow Transplantation |
| Publisher | wiley |
| Pages | 188-193 |
| Number of pages | 6 |
| ISBN (Electronic) | 9781119095491 |
| ISBN (Print) | 9781119095453 |
| DOIs | |
| State | Published - Jan 1 2017 |
Keywords
- Autologous hematopoietic cell transplant
- Bone marrow transplantation
- High-dose chemotherapy
- High-dose methotrexate
- Primary central nervous system lymphoma
- Whole-brain radiation therapy
