Prevention of breast cancer by RANKL/RANK blockade

Lorenzo Galluzzi; Aitziber Buqué; Guido Kroemer

doi:10.1038/cr.2016.79

Prevention of breast cancer by RANKL/RANK blockade

Lorenzo Galluzzi, Aitziber Buqué, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Robust genetic evidence in mice and humans indicates that RANK signaling plays a major role in mammary carcinogenesis driven by BRCA1/BRCA2 mutations. These findings may inaugurate a new era of breast cancer prevention, changing the life of millions of women worldwide.

Original language	English
Pages (from-to)	751-752
Number of pages	2
Journal	Cell Research
Volume	26
Issue number	7
DOIs	https://doi.org/10.1038/cr.2016.79
State	Published - Jul 1 2016
Externally published	Yes

Keywords

Animals
Breast Neoplasms
Cell Transformation, Neoplastic
Female
Humans
Mice
Mutation
Receptor Activator of Nuclear Factor-kappa B/genetics
Signal Transduction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/cr.2016.79

Cite this

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title = "Prevention of breast cancer by RANKL/RANK blockade",

abstract = "Robust genetic evidence in mice and humans indicates that RANK signaling plays a major role in mammary carcinogenesis driven by BRCA1/BRCA2 mutations. These findings may inaugurate a new era of breast cancer prevention, changing the life of millions of women worldwide.",

keywords = "Animals, Breast Neoplasms, Cell Transformation, Neoplastic, Female, Humans, Mice, Mutation, Receptor Activator of Nuclear Factor-kappa B/genetics, Signal Transduction",

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AU - Galluzzi, Lorenzo

AU - Buqué, Aitziber

AU - Kroemer, Guido

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KW - Animals

KW - Breast Neoplasms

KW - Cell Transformation, Neoplastic

KW - Female

KW - Humans

KW - Mice

KW - Mutation

KW - Receptor Activator of Nuclear Factor-kappa B/genetics

KW - Signal Transduction

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SP - 751

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JO - Cell Research

JF - Cell Research

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Prevention of breast cancer by RANKL/RANK blockade

Abstract

Keywords

UN SDGs

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