Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients

Camille Ragin; Karthik Devarajan; Jeffrey  Chang-Jen Liu; Giera Jones; Olubunmi Shoyele; Bukola Sowunmi; Rachel Kennett; Denise Gibbs; Elizabeth Blackman; Michael Esan; Margaret Brandwein-Gensler; Francesco Bussu; Rebecca Chernock; Chih Yen Chien; Marc A. Cohen; Samir El-Mofty; Mikio Suzuki; Gypsyamber D'Souza; Pauline Funchain; Charis Eng; Susanne M. Gollin; Angela Hong; Yuh S. Jung; Maximilian Krüger; James Lewis; Patrizia Morbini; Santo Landolfo; Massimo Rittà; Jos Straetmans; Krisztina Szarka; Ruth Tachezy; Francis P. Worden; Deborah B. Nelson; Samuel Gathere; Emanuela Taioli

doi:10.1093/carcin/bgw203

Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients

Camille Ragin
, Karthik Devarajan
, Jeffrey Chang-Jen Liu
, Giera Jones
, Olubunmi Shoyele
, Bukola Sowunmi
, Rachel Kennett
, Denise Gibbs
, Elizabeth Blackman
, Michael Esan
, Margaret Brandwein-Gensler
, Francesco Bussu
, Rebecca Chernock
, Chih Yen Chien
, Marc A. Cohen
, Samir El-Mofty
, Mikio Suzuki
, Gypsyamber D'Souza
, Pauline Funchain
, Charis Eng

Susanne M. Gollin, Angela Hong, Yuh S. Jung, Maximilian Krüger, James Lewis, Patrizia Morbini, Santo Landolfo, Massimo Rittà, Jos Straetmans, Krisztina Szarka, Ruth Tachezy, Francis P. Worden, Deborah B. Nelson, Samuel Gathere, Emanuela Taioli

Temple University
Danbury Hospital
Fox Chase Cancer Center
SUNY Buffalo
Fondazione Policlinico Universitario A. Gemelli IRCCS
Washington University St. Louis
Chang Gung University
Memorial Sloan-Kettering Cancer Center
University of the Ryukyus
Johns Hopkins University
Cleveland Clinic Foundation
University of Pittsburgh
University of Sydney
National Cancer Center Korea
Johannes Gutenberg University Mainz
Vanderbilt University
IRCCS Fondazione Policlinico San Matteo - Pavia
University of Turin
Maastricht University
University of Debrecen
Institute of Hematology and Blood Transfusion
University of Michigan, Ann Arbor
Kenya Medical Research Institute
Icahn School of Medicine at Mount Sinai
African Caribbean Cancer Consortium
University of Alabama at Birmingham
Sassari University Hospital
Cliniche San Pietro
Ohio State University
Ohio University
Beckman Research Institute of City of Hope
University of Pavia
SUNY Downstate Health Sciences University
North Shore Long Island Jewish/Hofstra School of Medicine
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
Northwell Health System
Mount Sinai
University of Milan
Cornell University
Division of Cancer Prevention and Population Science

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P < 0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P < 0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P < 0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.

Original language	English
Article number	bgw203
Pages (from-to)	218-229
Number of pages	12
Journal	Carcinogenesis
Volume	38
Issue number	2
DOIs	https://doi.org/10.1093/carcin/bgw203
State	Published - Feb 1 2017

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Ragin, C., Devarajan, K., Liu, J. C.-J., Jones, G., Shoyele, O., Sowunmi, B., Kennett, R., Gibbs, D., Blackman, E., Esan, M., Brandwein-Gensler, M., Bussu, F., Chernock, R., Chien, C. Y., Cohen, M. A., El-Mofty, S., Suzuki, M., D'Souza, G., Funchain, P., ... Taioli, E. (2017). Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients. Carcinogenesis, 38(2), 218-229. Article bgw203. https://doi.org/10.1093/carcin/bgw203

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title = "Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients",

abstract = "The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P < 0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1\%), followed by 58.0\% in Blacks and 25.2\% in Asians (P < 0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3\%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6\%, respectively) [P < 0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.",

author = "Camille Ragin and Karthik Devarajan and Liu, \{Jeffrey Chang-Jen\} and Giera Jones and Olubunmi Shoyele and Bukola Sowunmi and Rachel Kennett and Denise Gibbs and Elizabeth Blackman and Michael Esan and Margaret Brandwein-Gensler and Francesco Bussu and Rebecca Chernock and Chien, \{Chih Yen\} and Cohen, \{Marc A.\} and Samir El-Mofty and Mikio Suzuki and Gypsyamber D'Souza and Pauline Funchain and Charis Eng and Gollin, \{Susanne M.\} and Angela Hong and Jung, \{Yuh S.\} and Maximilian Kr{\"u}ger and James Lewis and Patrizia Morbini and Santo Landolfo and Massimo Ritt{\`a} and Jos Straetmans and Krisztina Szarka and Ruth Tachezy and Worden, \{Francis P.\} and Nelson, \{Deborah B.\} and Samuel Gathere and Emanuela Taioli",

year = "2017",

month = feb,

day = "1",

doi = "10.1093/carcin/bgw203",

language = "English",

volume = "38",

pages = "218--229",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "2",

}

Ragin, C , Devarajan, K, Liu, JC-J, Jones, G, Shoyele, O, Sowunmi, B, Kennett, R, Gibbs, D, Blackman, E, Esan, M, Brandwein-Gensler, M, Bussu, F, Chernock, R, Chien, CY, Cohen, MA, El-Mofty, S, Suzuki, M, D'Souza, G, Funchain, P, Eng, C, Gollin, SM, Hong, A, Jung, YS, Krüger, M, Lewis, J, Morbini, P, Landolfo, S, Rittà, M, Straetmans, J, Szarka, K, Tachezy, R, Worden, FP, Nelson, DB, Gathere, S & Taioli, E 2017, 'Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients', Carcinogenesis, vol. 38, no. 2, bgw203, pp. 218-229. https://doi.org/10.1093/carcin/bgw203

TY - JOUR

T1 - Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients

AU - Ragin, Camille

AU - Devarajan, Karthik

AU - Liu, Jeffrey Chang-Jen

AU - Jones, Giera

AU - Shoyele, Olubunmi

AU - Sowunmi, Bukola

AU - Kennett, Rachel

AU - Gibbs, Denise

AU - Blackman, Elizabeth

AU - Esan, Michael

AU - Brandwein-Gensler, Margaret

AU - Bussu, Francesco

AU - Chernock, Rebecca

AU - Chien, Chih Yen

AU - Cohen, Marc A.

AU - El-Mofty, Samir

AU - Suzuki, Mikio

AU - D'Souza, Gypsyamber

AU - Funchain, Pauline

AU - Eng, Charis

AU - Gollin, Susanne M.

AU - Hong, Angela

AU - Jung, Yuh S.

AU - Krüger, Maximilian

AU - Lewis, James

AU - Morbini, Patrizia

AU - Landolfo, Santo

AU - Rittà, Massimo

AU - Straetmans, Jos

AU - Szarka, Krisztina

AU - Tachezy, Ruth

AU - Worden, Francis P.

AU - Nelson, Deborah B.

AU - Gathere, Samuel

AU - Taioli, Emanuela

PY - 2017/2/1

Y1 - 2017/2/1

N2 - The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P < 0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P < 0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P < 0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.

AB - The landscape of human papillomavirus (HPV) infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate HPV prevalence and patterns of p16 (CDNK2A) expression amongst different racial groups. Eighteen publications (N = 798 Black HNC patients) were examined in the meta-analysis, and the pooled analysis included 29 datasets comprised of 3129 HNC patients of diverse racial/ethnic background. The meta-analysis revealed that the prevalence of HPV16 was higher among Blacks with oropharyngeal cancer than Blacks with non-oropharyngeal cancer. However, there was great heterogeneity observed among studies (Q test P < 0.0001). In the pooled analysis, after adjusting for each study, year of diagnosis, age, gender and smoking status, the prevalence of HPV16,18 in oropharyngeal cancer patients was highest in Whites (61.1%), followed by 58.0% in Blacks and 25.2% in Asians (P < 0.0001). There was no statistically significant difference in HPV16,18 prevalence in nonoropharyngeal cancer by race (P = 0.682). With regard to the pattern of HPV16,18 status and p16 expression, White patients had the highest proportion of HPV16,18+/p16+ oropharyngeal cancer (52.3%), while Asians and Blacks had significantly lower proportions (23.0 and 22.6%, respectively) [P < 0.0001]. Our findings suggest that the pattern of HPV16,18 status and p16 expression in oropharyngeal cancer appears to differ by race and this may contribute to survival disparities.

UR - https://www.scopus.com/pages/publications/85019757527

U2 - 10.1093/carcin/bgw203

DO - 10.1093/carcin/bgw203

M3 - Article

C2 - 28025390

SN - 0143-3334

VL - 38

SP - 218

EP - 229

JO - Carcinogenesis

JF - Carcinogenesis

IS - 2

M1 - bgw203

ER -

Prevalence of HPV infection in racial-ethnic subgroups of head and neck cancer patients

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