TY - GEN
T1 - Preparation of interconnected microporous poly(glycolic-co-lactic acid) with high hydroxyapatite loading
AU - Zhang, Wei
AU - Yao, Donggang
AU - Zhang, Qingwei
AU - Zhou, Jack G.
AU - Lelkes, Peter I.
PY - 2010
Y1 - 2010
N2 - Hydroxyapatite (HA) is known to promote osteogenicity and enhance mechanical strength of biopolymers. However, incorporating a large amount of HA into a porous biopolymer still remains a challenge. In this study, a new method was investigated to incorporate high HA loading into interconnected microporous poly(glycolic-co-lactic acid) (PLGA). Specifically, a tertiary blend comprising PLGA/PS/HA (40/40/20 wt%), prepared by melt blending under conditions for formation of a co-continuous structure, was annealed under small-strain oscillation between parallel plates. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%.
AB - Hydroxyapatite (HA) is known to promote osteogenicity and enhance mechanical strength of biopolymers. However, incorporating a large amount of HA into a porous biopolymer still remains a challenge. In this study, a new method was investigated to incorporate high HA loading into interconnected microporous poly(glycolic-co-lactic acid) (PLGA). Specifically, a tertiary blend comprising PLGA/PS/HA (40/40/20 wt%), prepared by melt blending under conditions for formation of a co-continuous structure, was annealed under small-strain oscillation between parallel plates. The results from different characterizations suggested that the applied small-strain oscillation substantially accelerated the migration of HA nanoparticles during annealing from the PS phase to the PLGA phase; nearly all HA particles were uniformly presented in the PLGA phase after a short period of annealing. After dissolution of the PS phase, a PLGA material with interconnected microporous structure was successfully produced, with a high HA loading above 30 wt%.
UR - http://www.scopus.com/inward/record.url?scp=77955068003&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000282210100083&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1115/nemb2010-13119
DO - 10.1115/nemb2010-13119
M3 - Conference contribution
SN - 9780791843925
T3 - Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
SP - 199
EP - 202
BT - Proceedings of the ASME 1st Global Congress on NanoEngineering for Medicine and Biology 2010, NEMB2010
PB - ASME
T2 - 1st Global Congress on NanoEngineering for Medicine and Biology: Advancing Health Care through NanoEngineering and Computing, NEMB 2010
Y2 - 7 February 2010 through 10 February 2010
ER -