Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy

Ronald J. Wapner; Thomas M. Jenkins; Neil Silverman; Marion Kaufmann; Cheryl Hannau; Peter McCue

doi:10.1002/pd.38

Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy

Ronald J. Wapner
, Thomas M. Jenkins
, Neil Silverman
, Marion Kaufmann
, Cheryl Hannau
, Peter McCue

Pathology

Thomas Jefferson University

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.

Original language	English
Pages (from-to)	256-261
Number of pages	6
Journal	Prenatal Diagnosis
Volume	21
Issue number	4
DOIs	https://doi.org/10.1002/pd.38
State	Published - 2001

Keywords

Acetylcholinesterase/analysis
Adult
Amniotic Fluid/chemistry
Biopsy
Female
Fetal Diseases/diagnosis
Gestational Age
Humans
Kidney/pathology
Nephrosis/congenital
Pregnancy
Prenatal Diagnosis
Ultrasonography, Prenatal
alpha-Fetoproteins/analysis

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10.1002/pd.38

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title = "Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy",

abstract = "The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.",

keywords = "Acetylcholinesterase/analysis, Adult, Amniotic Fluid/chemistry, Biopsy, Female, Fetal Diseases/diagnosis, Gestational Age, Humans, Kidney/pathology, Nephrosis/congenital, Pregnancy, Prenatal Diagnosis, Ultrasonography, Prenatal, alpha-Fetoproteins/analysis",

author = "Wapner, \{Ronald J.\} and Jenkins, \{Thomas M.\} and Neil Silverman and Marion Kaufmann and Cheryl Hannau and Peter McCue",

year = "2001",

doi = "10.1002/pd.38",

language = "English",

volume = "21",

pages = "256--261",

journal = "Prenatal Diagnosis",

issn = "0197-3851",

publisher = "John Wiley and Sons Ltd",

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TY - JOUR

T1 - Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy

AU - Wapner, Ronald J.

AU - Jenkins, Thomas M.

AU - Silverman, Neil

AU - Kaufmann, Marion

AU - Hannau, Cheryl

AU - McCue, Peter

PY - 2001

Y1 - 2001

N2 - The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.

AB - The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.

KW - Acetylcholinesterase/analysis

KW - Adult

KW - Amniotic Fluid/chemistry

KW - Biopsy

KW - Female

KW - Fetal Diseases/diagnosis

KW - Gestational Age

KW - Humans

KW - Kidney/pathology

KW - Nephrosis/congenital

KW - Pregnancy

KW - Prenatal Diagnosis

KW - Ultrasonography, Prenatal

KW - alpha-Fetoproteins/analysis

UR - https://www.scopus.com/pages/publications/0035012868

U2 - 10.1002/pd.38

DO - 10.1002/pd.38

M3 - Article

C2 - 11288113

AN - SCOPUS:0035012868

SN - 0197-3851

VL - 21

SP - 256

EP - 261

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 4

ER -

Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy

Abstract

Keywords

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