TY - JOUR
T1 - Preclinical Models of Malignant Mesothelioma
AU - Testa, Joseph R.
AU - Berns, Anton
N1 - Publisher Copyright:
© Copyright © 2020 Testa and Berns.
PY - 2020/2/11
Y1 - 2020/2/11
N2 - Rodent models of malignant mesothelioma help facilitate the understanding of the biology of this highly lethal cancer and to develop and test new interventions. Introducing the same genetic lesions as found in human mesothelioma in mice results in tumors that show close resemblance with the human disease counterpart. This includes the extensive inflammatory responses that characterize human malignant mesothelioma. The relatively fast development of mesothelioma in mice when the appropriate combination of lesions is introduced, with or without exposure to asbestos, make the autochthonous models particularly useful for testing new treatment strategies in an immunocompetent setting, whereas Patient-Derived Xenograft models are particularly useful to assess effects of inter- and intra-tumor heterogeneity and human-specific features of mesothelioma. It is to be expected that new insights obtained by studying these experimental systems will lead to new more effective treatments for this devastating disease.
AB - Rodent models of malignant mesothelioma help facilitate the understanding of the biology of this highly lethal cancer and to develop and test new interventions. Introducing the same genetic lesions as found in human mesothelioma in mice results in tumors that show close resemblance with the human disease counterpart. This includes the extensive inflammatory responses that characterize human malignant mesothelioma. The relatively fast development of mesothelioma in mice when the appropriate combination of lesions is introduced, with or without exposure to asbestos, make the autochthonous models particularly useful for testing new treatment strategies in an immunocompetent setting, whereas Patient-Derived Xenograft models are particularly useful to assess effects of inter- and intra-tumor heterogeneity and human-specific features of mesothelioma. It is to be expected that new insights obtained by studying these experimental systems will lead to new more effective treatments for this devastating disease.
KW - conditional tumor suppressor gene knockout/oncogene mouse models
KW - genetic driver lesions
KW - in vivo asbestos carcinogenesis
KW - malignant mesothelioma
KW - mesothelioma inflammatory phenotype
KW - patient-derived xenograft models of mesothelioma
KW - preclinical rodent models
UR - http://www.scopus.com/inward/record.url?scp=85083619061&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000517498500001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.3389/fonc.2020.00101
DO - 10.3389/fonc.2020.00101
M3 - Review article
C2 - 32117751
SN - 2234-943X
VL - 10
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 101
ER -