Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold

Boyeong Kang; Woojin Yang; Sebok Lee; Sudipto Mukherjee; Jonathan Forstater; Hanna Kim; Byoungsook Goh; Tae Young Kim; Vincent A. Voelz; Yoonsoo Pang; Jiwon Seo

doi:10.1038/s41598-017-04727-0

Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold

Boyeong Kang, Woojin Yang, Sebok Lee, Sudipto Mukherjee, Jonathan Forstater, Hanna Kim, Byoungsook Goh, Tae Young Kim, Vincent A. Voelz, Yoonsoo Pang, Jiwon Seo

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficiency with exceptional precision by controlling the relative distance and orientation of the two pigments. Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)-Zn(i + 6)), and highly efficient energy transfer was demonstrated with estimated efficiencies ranging from 92% to 96% measured by static fluorescence emission in CH₂Cl₂ and from 96.3% to 97.6% using femtosecond transient absorption measurements in toluene, depending on the relative spatial arrangement of the donor-acceptor pairs. Our results suggest that the remarkable precision and tunability exhibited by nature can be achieved by mimicking the design principles of natural photosynthetic proteins.

Original language	English
Article number	4786
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-04727-0
State	Published - Dec 1 2017
Externally published	Yes

Access to Document

10.1038/s41598-017-04727-0

Cite this

@article{39467c1ef1654f0c8d3b6946ae68a9f6,

title = "Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold",

abstract = "The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficiency with exceptional precision by controlling the relative distance and orientation of the two pigments. Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)-Zn(i + 6)), and highly efficient energy transfer was demonstrated with estimated efficiencies ranging from 92\% to 96\% measured by static fluorescence emission in CH2Cl2 and from 96.3\% to 97.6\% using femtosecond transient absorption measurements in toluene, depending on the relative spatial arrangement of the donor-acceptor pairs. Our results suggest that the remarkable precision and tunability exhibited by nature can be achieved by mimicking the design principles of natural photosynthetic proteins.",

author = "Boyeong Kang and Woojin Yang and Sebok Lee and Sudipto Mukherjee and Jonathan Forstater and Hanna Kim and Byoungsook Goh and Kim, \{Tae Young\} and Voelz, \{Vincent A.\} and Yoonsoo Pang and Jiwon Seo",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = dec,

day = "1",

doi = "10.1038/s41598-017-04727-0",

language = "English",

volume = "7",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold

AU - Kang, Boyeong

AU - Yang, Woojin

AU - Lee, Sebok

AU - Mukherjee, Sudipto

AU - Forstater, Jonathan

AU - Kim, Hanna

AU - Goh, Byoungsook

AU - Kim, Tae Young

AU - Voelz, Vincent A.

AU - Pang, Yoonsoo

AU - Seo, Jiwon

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficiency with exceptional precision by controlling the relative distance and orientation of the two pigments. Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)-Zn(i + 6)), and highly efficient energy transfer was demonstrated with estimated efficiencies ranging from 92% to 96% measured by static fluorescence emission in CH2Cl2 and from 96.3% to 97.6% using femtosecond transient absorption measurements in toluene, depending on the relative spatial arrangement of the donor-acceptor pairs. Our results suggest that the remarkable precision and tunability exhibited by nature can be achieved by mimicking the design principles of natural photosynthetic proteins.

AB - The energy flow during natural photosynthesis is controlled by maintaining the spatial arrangement of pigments, employing helices as scaffolds. In this study, we have developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor energy transfer efficiency with exceptional precision by controlling the relative distance and orientation of the two pigments. Five donor-acceptor molecular dyads were constructed using zinc porphyrin and free base porphyrin (Zn(i + 2)-Zn(i + 6)), and highly efficient energy transfer was demonstrated with estimated efficiencies ranging from 92% to 96% measured by static fluorescence emission in CH2Cl2 and from 96.3% to 97.6% using femtosecond transient absorption measurements in toluene, depending on the relative spatial arrangement of the donor-acceptor pairs. Our results suggest that the remarkable precision and tunability exhibited by nature can be achieved by mimicking the design principles of natural photosynthetic proteins.

UR - http://www.scopus.com/inward/record.url?scp=85021954112&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-04727-0

DO - 10.1038/s41598-017-04727-0

M3 - Article

SN - 2045-2322

VL - 7

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 4786

ER -

Precisely tuneable energy transfer system using peptoid helix-based molecular scaffold

Abstract

Access to Document

Other files and links

Fingerprint

Cite this