PRC2 Plays Red Light, Green Light with MHC-I and CD8+ T Cells

Johnathan R. Whetstine

doi:10.1016/j.ccell.2019.09.010

PRC2 Plays Red Light, Green Light with MHC-I and CD8⁺ T Cells

Johnathan R. Whetstine

Research output: Contribution to journal › Short survey › peer-review

Abstract

In this issue of Cancer Cell, Burr et al. report that PRC2 plays a conserved role in silencing antigen presentation and processing genes and, in turn, CD8⁺ T cell activation. Furthermore, PRC2-targeted therapeutics overcome gene silencing and promote tumor clearance by cytotoxic T cells.

Original language	English
Pages (from-to)	343-345
Number of pages	3
Journal	Cancer Cell
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2019.09.010
State	Published - Oct 14 2019

Keywords

Antigen Presentation
CD8-Positive T-Lymphocytes/immunology
Histocompatibility Antigens Class I
Humans
Immune Evasion
Neoplasms
T-Lymphocytes, Cytotoxic/immunology

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10.1016/j.ccell.2019.09.010

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title = "PRC2 Plays Red Light, Green Light with MHC-I and CD8+ T Cells",

abstract = "In this issue of Cancer Cell, Burr et al. report that PRC2 plays a conserved role in silencing antigen presentation and processing genes and, in turn, CD8+ T cell activation. Furthermore, PRC2-targeted therapeutics overcome gene silencing and promote tumor clearance by cytotoxic T cells.",

keywords = "Antigen Presentation, CD8-Positive T-Lymphocytes/immunology, Histocompatibility Antigens Class I, Humans, Immune Evasion, Neoplasms, T-Lymphocytes, Cytotoxic/immunology",

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year = "2019",

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journal = "Cancer Cell",

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AU - Whetstine, Johnathan R.

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AB - In this issue of Cancer Cell, Burr et al. report that PRC2 plays a conserved role in silencing antigen presentation and processing genes and, in turn, CD8+ T cell activation. Furthermore, PRC2-targeted therapeutics overcome gene silencing and promote tumor clearance by cytotoxic T cells.

KW - Antigen Presentation

KW - CD8-Positive T-Lymphocytes/immunology

KW - Histocompatibility Antigens Class I

KW - Humans

KW - Immune Evasion

KW - Neoplasms

KW - T-Lymphocytes, Cytotoxic/immunology

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DO - 10.1016/j.ccell.2019.09.010

M3 - Short survey

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SN - 1535-6108

VL - 36

SP - 343

EP - 345

JO - Cancer Cell

JF - Cancer Cell

IS - 4

ER -

PRC2 Plays Red Light, Green Light with MHC-I and CD8⁺ T Cells

Abstract

Keywords

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