TY - JOUR
T1 - pRB, p107 and p130 as transcriptional regulators
T2 - role in cell growth and differentiation.
AU - Mayol, X.
AU - Graña, X.
PY - 1997
Y1 - 1997
N2 - The mammalian cell cycle engine, which is composed of cyclin/CDK holoenzymes, controls the progression throughout the cell cycle by regulating, at least in part, the transcription of two types of genes: genes whose protein products are required for DNA metabolism and genes whose protein products are involved in cell cycle control. Among the targets of cyclin/CDKs, there is a family of negative growth regulators collectively known as pocket proteins. This family of pocket proteins includes the product of the retinoblastoma tumor suppressor gene, pRB and the functionally and structurally related proteins p107 and p130. In this review, the mechanisms by which pocket proteins are thought to regulate cell growth and differentiation are discussed.
AB - The mammalian cell cycle engine, which is composed of cyclin/CDK holoenzymes, controls the progression throughout the cell cycle by regulating, at least in part, the transcription of two types of genes: genes whose protein products are required for DNA metabolism and genes whose protein products are involved in cell cycle control. Among the targets of cyclin/CDKs, there is a family of negative growth regulators collectively known as pocket proteins. This family of pocket proteins includes the product of the retinoblastoma tumor suppressor gene, pRB and the functionally and structurally related proteins p107 and p130. In this review, the mechanisms by which pocket proteins are thought to regulate cell growth and differentiation are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0031301803&partnerID=8YFLogxK
U2 - 10.1007/978-1-4615-5371-7_13
DO - 10.1007/978-1-4615-5371-7_13
M3 - Review article
SN - 1087-2957
VL - 3
SP - 157
EP - 169
JO - Progress in cell cycle research
JF - Progress in cell cycle research
ER -