Possible mechanisms of cancer prevention by nicotinamide

Aitziber Buqué; Norma Bloy; Guido Kroemer; Lorenzo Galluzzi

doi:10.1111/bph.15096

Possible mechanisms of cancer prevention by nicotinamide

Aitziber Buqué, Norma Bloy, Guido Kroemer, Lorenzo Galluzzi

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

Nicotinamide (NAM) is a precursor of vitamin B₃ commonly sold over the counter as a nutritional supplement with anti-aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial have demonstrated that oral NAM was safe and efficiently reduced the incidence of new non-melanoma skin cancers and actinic keratosis amongst high-risk individuals. However, the molecular and cellular mechanisms that underlie this ability of NAM to delay carcinogenesis remain to be clarified, as discussed in this short review. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.

Original language	English
Pages (from-to)	2034-2040
Number of pages	7
Journal	British Journal of Pharmacology
Volume	178
Issue number	10
DOIs	https://doi.org/10.1111/bph.15096
State	Published - May 2021
Externally published	Yes

Keywords

Dietary Supplements
Humans
Neoplasms/prevention & control
Niacinamide
Randomized Controlled Trials as Topic

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bph.15096

Cite this

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title = "Possible mechanisms of cancer prevention by nicotinamide",

abstract = "Nicotinamide (NAM) is a precursor of vitamin B3 commonly sold over the counter as a nutritional supplement with anti-aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial have demonstrated that oral NAM was safe and efficiently reduced the incidence of new non-melanoma skin cancers and actinic keratosis amongst high-risk individuals. However, the molecular and cellular mechanisms that underlie this ability of NAM to delay carcinogenesis remain to be clarified, as discussed in this short review. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.",

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author = "Aitziber Buqu{\'e} and Norma Bloy and Guido Kroemer and Lorenzo Galluzzi",

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year = "2021",

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doi = "10.1111/bph.15096",

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volume = "178",

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T1 - Possible mechanisms of cancer prevention by nicotinamide

AU - Buqué, Aitziber

AU - Bloy, Norma

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

PY - 2021/5

Y1 - 2021/5

N2 - Nicotinamide (NAM) is a precursor of vitamin B3 commonly sold over the counter as a nutritional supplement with anti-aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial have demonstrated that oral NAM was safe and efficiently reduced the incidence of new non-melanoma skin cancers and actinic keratosis amongst high-risk individuals. However, the molecular and cellular mechanisms that underlie this ability of NAM to delay carcinogenesis remain to be clarified, as discussed in this short review. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.

AB - Nicotinamide (NAM) is a precursor of vitamin B3 commonly sold over the counter as a nutritional supplement with anti-aging properties. Accumulating preclinical evidence indicates that NAM also mediates oncopreventive effects against a variety of neoplasms. Supporting the translational relevance of dietary NAM supplementation, results from a Phase 3 randomized clinical trial have demonstrated that oral NAM was safe and efficiently reduced the incidence of new non-melanoma skin cancers and actinic keratosis amongst high-risk individuals. However, the molecular and cellular mechanisms that underlie this ability of NAM to delay carcinogenesis remain to be clarified, as discussed in this short review. LINKED ARTICLES: This article is part of a themed issue on Cellular metabolism and diseases. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v178.10/issuetoc.

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KW - Niacinamide

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Possible mechanisms of cancer prevention by nicotinamide

Abstract

Keywords

UN SDGs

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