TY - JOUR
T1 - Phase II trial of weekly or biweekly intraperitoneal mitoxantrone in epithelial ovarian cancer
AU - Markman, Maurie
AU - Hakes, Thomas
AU - Reichman, Bonnie
AU - Lewis, John L.
AU - Rubin, Stephen
AU - Jones, Walter
AU - Almadrones, Lois
AU - Hoskins, William
PY - 1991
Y1 - 1991
N2 - Previous experimental and clinical evaluation has suggested that ovarian cancer is sensitive to the cytotoxic effects of mitoxantrone at concentrations achievable within the peritoneal cavity after intraperitoneal (IP) administration. Unfortunately, the use of the drug delivered IP at high doses (20 mg/m2 in 2 L normal saline [NS]) on a monthly schedule is compromised by severe local effects secondary to the irritant properties of the drug. To reduce toxicity and take advantage of minimal systemic drug exposure following IP administration, we treated 28 patients with a lower drug concentration of mitoxantrone (10 mg/m2 in 2 L NS), but on a weekly or every other week schedule (total, 12 courses). Compared with the monthly program, this regimen caused less pain, allowed for a higher cumulative dose of mitoxantrone to be delivered, and resulted in less serious treatment-related morbidity. Four of 13 assessable patients (31%) whose largest tumor was ≤ 1 cm in diameter demonstrated a surgically defined response. All responding patients had failed previously or exhibited a minimal response to cisplatin. Despite the improved toxicity profile of this regimen, the overall response rate was similar to the monthly program, probably secondary to inadequate IP drug distribution in many patients. Future investigative efforts using IP mitoxantrone as therapy for ovarian cancer might focus on developing methods to improve drug delivery to all sites of tumor within the peritoneal cavity (eg, intraoperative therapy, increased treatment volumes, and antiinflammatory agents to reduce adhesion formation).
AB - Previous experimental and clinical evaluation has suggested that ovarian cancer is sensitive to the cytotoxic effects of mitoxantrone at concentrations achievable within the peritoneal cavity after intraperitoneal (IP) administration. Unfortunately, the use of the drug delivered IP at high doses (20 mg/m2 in 2 L normal saline [NS]) on a monthly schedule is compromised by severe local effects secondary to the irritant properties of the drug. To reduce toxicity and take advantage of minimal systemic drug exposure following IP administration, we treated 28 patients with a lower drug concentration of mitoxantrone (10 mg/m2 in 2 L NS), but on a weekly or every other week schedule (total, 12 courses). Compared with the monthly program, this regimen caused less pain, allowed for a higher cumulative dose of mitoxantrone to be delivered, and resulted in less serious treatment-related morbidity. Four of 13 assessable patients (31%) whose largest tumor was ≤ 1 cm in diameter demonstrated a surgically defined response. All responding patients had failed previously or exhibited a minimal response to cisplatin. Despite the improved toxicity profile of this regimen, the overall response rate was similar to the monthly program, probably secondary to inadequate IP drug distribution in many patients. Future investigative efforts using IP mitoxantrone as therapy for ovarian cancer might focus on developing methods to improve drug delivery to all sites of tumor within the peritoneal cavity (eg, intraoperative therapy, increased treatment volumes, and antiinflammatory agents to reduce adhesion formation).
KW - Adult
KW - Aged
KW - Drug Administration Schedule
KW - Drug Evaluation
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Injections, Intraperitoneal
KW - Middle Aged
KW - Mitoxantrone/administration & dosage
KW - Neoplasm Recurrence, Local
KW - Ovarian Neoplasms/drug therapy
KW - Prognosis
KW - Survival Rate
UR - http://www.scopus.com/inward/record.url?scp=0025825680&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:A1991FP23800012&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1200/JCO.1991.9.6.978
DO - 10.1200/JCO.1991.9.6.978
M3 - Article
C2 - 2033432
SN - 0732-183X
VL - 9
SP - 978
EP - 982
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 6
ER -