Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies

Tariq I. Mughal; Naveen Pemmaraju; Rafael Bejar; Robert P. Gale; Prithviraj Bose; Jean Jacques Kiladjian; Josef Prchal; Daniel Royston; Daniel A. Pollyea; Peter Valent; Tim H. Brümmendorf; Tomasz Skorski; Mrinal Patnaik; Valeria Santini; Pierre Fenaux; Nicole Kucine; Srdan Verstovsek; Ruben Mesa; Tiziano Barbui; Giuseppe Saglio; Richard A. Van Etten

doi:10.1002/hon.2987

Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies

Tariq I. Mughal
, Naveen Pemmaraju
, Rafael Bejar
, Robert P. Gale
, Prithviraj Bose
, Jean Jacques Kiladjian
, Josef Prchal
, Daniel Royston
, Daniel A. Pollyea
, Peter Valent
, Tim H. Brümmendorf
, Tomasz Skorski
, Mrinal Patnaik
, Valeria Santini
, Pierre Fenaux
, Nicole Kucine
, Srdan Verstovsek
, Ruben Mesa
, Tiziano Barbui
, Giuseppe Saglio

Richard A. Van Etten

Tufts University
The University of Buckingham
University of Texas MD Anderson Cancer Center
University of California at San Diego
Imperial College London
Université Paris Cité
University of Utah
University of Oxford
University of Colorado Anschutz Medical Campus
Medical University of Vienna
RWTH Aachen University
Mayo Clinic
Azienda Ospedaliera Careggi
Cornell University
University of Texas
IRCCS Fondazione Ca'Granda – Ospedale Maggiore Policlinico - Milano
University of Turin
University of California at Irvine
Baylor College of Medicine
University of Colorado Cancer Center
University of Colorado
Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
University of Texas Health Science Center at Houston
Tufts Medical Center

Research output: Contribution to journal › Review article › peer-review

Abstract

Despite much of the past 2 years being engulfed by the devastating consequences of the SAR-CoV-2 pandemic, significant progress, even breathtaking, occurred in the field of chronic myeloid malignancies. Some of this was show-cased at the 15th Post-American Society of Hematology (ASH) and the 25th John Goldman workshops on myeloproliferative neoplasms (MPN) held on 9th-10th December 2020 and 7th-10th October 2021, respectively. The inaugural Post-ASH MPN workshop was set out in 2006 by John Goldman (deceased) and Tariq Mughal to answer emerging translational hematology and therapeutics of patients with these malignancies. Rather than present a resume of the discussions, this perspective focuses on some of the pivotal translational hematology and therapeutic insights in these diseases.

Original language	English
Pages (from-to)	491-504
Number of pages	14
Journal	Hematological Oncology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1002/hon.2987
State	Published - Oct 2022

Keywords

Myelofibrosis
chronic myeloid leukemia
clinical
systemic mastocytosis
thrombosis
translational

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10.1002/hon.2987

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Mughal, T. I., Pemmaraju, N., Bejar, R., Gale, R. P., Bose, P., Kiladjian, J. J., Prchal, J., Royston, D., Pollyea, D. A., Valent, P., Brümmendorf, T. H., Skorski, T., Patnaik, M., Santini, V., Fenaux, P., Kucine, N., Verstovsek, S., Mesa, R., Barbui, T., ... Van Etten, R. A. (2022). Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies. Hematological Oncology, 40(4), 491-504. https://doi.org/10.1002/hon.2987

@article{01465b7c24f34cee8ac8956c19eab797,

title = "Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies",

abstract = "Despite much of the past 2 years being engulfed by the devastating consequences of the SAR-CoV-2 pandemic, significant progress, even breathtaking, occurred in the field of chronic myeloid malignancies. Some of this was show-cased at the 15th Post-American Society of Hematology (ASH) and the 25th John Goldman workshops on myeloproliferative neoplasms (MPN) held on 9th-10th December 2020 and 7th-10th October 2021, respectively. The inaugural Post-ASH MPN workshop was set out in 2006 by John Goldman (deceased) and Tariq Mughal to answer emerging translational hematology and therapeutics of patients with these malignancies. Rather than present a resume of the discussions, this perspective focuses on some of the pivotal translational hematology and therapeutic insights in these diseases.",

keywords = "Myelofibrosis, chronic myeloid leukemia, clinical, systemic mastocytosis, thrombosis, translational",

author = "Mughal, \{Tariq I.\} and Naveen Pemmaraju and Rafael Bejar and Gale, \{Robert P.\} and Prithviraj Bose and Kiladjian, \{Jean Jacques\} and Josef Prchal and Daniel Royston and Pollyea, \{Daniel A.\} and Peter Valent and Br{\"u}mmendorf, \{Tim H.\} and Tomasz Skorski and Mrinal Patnaik and Valeria Santini and Pierre Fenaux and Nicole Kucine and Srdan Verstovsek and Ruben Mesa and Tiziano Barbui and Giuseppe Saglio and \{Van Etten\}, \{Richard A.\}",

note = "Publisher Copyright: {\textcopyright} 2022 John Wiley \& Sons Ltd.",

year = "2022",

month = oct,

doi = "10.1002/hon.2987",

language = "English",

volume = "40",

pages = "491--504",

journal = "Hematological Oncology",

issn = "0278-0232",

publisher = "John Wiley and Sons Ltd",

number = "4",

}

Mughal, TI, Pemmaraju, N, Bejar, R, Gale, RP, Bose, P, Kiladjian, JJ, Prchal, J, Royston, D, Pollyea, DA, Valent, P, Brümmendorf, TH, Skorski, T, Patnaik, M, Santini, V, Fenaux, P, Kucine, N, Verstovsek, S, Mesa, R, Barbui, T, Saglio, G & Van Etten, RA 2022, 'Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies', Hematological Oncology, vol. 40, no. 4, pp. 491-504. https://doi.org/10.1002/hon.2987

TY - JOUR

T1 - Perspective

T2 - Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies

AU - Mughal, Tariq I.

AU - Pemmaraju, Naveen

AU - Bejar, Rafael

AU - Gale, Robert P.

AU - Bose, Prithviraj

AU - Kiladjian, Jean Jacques

AU - Prchal, Josef

AU - Royston, Daniel

AU - Pollyea, Daniel A.

AU - Valent, Peter

AU - Brümmendorf, Tim H.

AU - Skorski, Tomasz

AU - Patnaik, Mrinal

AU - Santini, Valeria

AU - Fenaux, Pierre

AU - Kucine, Nicole

AU - Verstovsek, Srdan

AU - Mesa, Ruben

AU - Barbui, Tiziano

AU - Saglio, Giuseppe

AU - Van Etten, Richard A.

PY - 2022/10

Y1 - 2022/10

N2 - Despite much of the past 2 years being engulfed by the devastating consequences of the SAR-CoV-2 pandemic, significant progress, even breathtaking, occurred in the field of chronic myeloid malignancies. Some of this was show-cased at the 15th Post-American Society of Hematology (ASH) and the 25th John Goldman workshops on myeloproliferative neoplasms (MPN) held on 9th-10th December 2020 and 7th-10th October 2021, respectively. The inaugural Post-ASH MPN workshop was set out in 2006 by John Goldman (deceased) and Tariq Mughal to answer emerging translational hematology and therapeutics of patients with these malignancies. Rather than present a resume of the discussions, this perspective focuses on some of the pivotal translational hematology and therapeutic insights in these diseases.

AB - Despite much of the past 2 years being engulfed by the devastating consequences of the SAR-CoV-2 pandemic, significant progress, even breathtaking, occurred in the field of chronic myeloid malignancies. Some of this was show-cased at the 15th Post-American Society of Hematology (ASH) and the 25th John Goldman workshops on myeloproliferative neoplasms (MPN) held on 9th-10th December 2020 and 7th-10th October 2021, respectively. The inaugural Post-ASH MPN workshop was set out in 2006 by John Goldman (deceased) and Tariq Mughal to answer emerging translational hematology and therapeutics of patients with these malignancies. Rather than present a resume of the discussions, this perspective focuses on some of the pivotal translational hematology and therapeutic insights in these diseases.

KW - Myelofibrosis

KW - chronic myeloid leukemia

KW - clinical

KW - systemic mastocytosis

KW - thrombosis

KW - translational

UR - https://www.scopus.com/pages/publications/85128176922

UR - https://pubmed.ncbi.nlm.nih.gov/35368098/

U2 - 10.1002/hon.2987

DO - 10.1002/hon.2987

M3 - Review article

C2 - 35368098

SN - 0278-0232

VL - 40

SP - 491

EP - 504

JO - Hematological Oncology

JF - Hematological Oncology

IS - 4

ER -

Perspective: Pivotal translational hematology and therapeutic insights in chronic myeloid hematopoietic stem cell malignancies

Abstract

Keywords

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