TY - JOUR
T1 - Pemetrexed with Platinum Combination as a Backbone for Targeted Therapy in Non-Small-Cell Lung Cancer
AU - Stinchcombe, Thomas E.
AU - Borghaei, Hossein
AU - Barker, Scott S.
AU - Treat, Joseph Anthony
AU - Obasaju, Coleman
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Standard platinum-based chemotherapy combinations for advanced non-small-cell lung cancer (NSCLC) have reached a plateau in terms of the survival benefit they offer for patients. In addition, the emerging clinical trend of tailored treatment based on patient characteristics has led to the development of therapeutic strategies that target specific cancer-related molecular pathways, including epidermal growth factor receptor (EGFR), angiogenesis, and anaplastic lymphoma kinase inhibitors. Current research is focused on combining targeted therapy with platinum-based chemotherapy in an endeavor to achieve an additional benefit in specific patient populations. Currently, pemetrexed is indicated for use in the first-line, maintenance, and second-line settings for the treatment of nonsquamous NSCLC. The combination of pemetrexed and cisplatin is well tolerated and is the approved standard first-line therapy. Thus, the pemetrexed-platinum backbone provides an attractive option for combination with targeted therapies. This review aims to summarize the current knowledge and future prospects of the use of pemetrexed-platinum as a backbone for combination with targeted therapies for NSCLC.
AB - Standard platinum-based chemotherapy combinations for advanced non-small-cell lung cancer (NSCLC) have reached a plateau in terms of the survival benefit they offer for patients. In addition, the emerging clinical trend of tailored treatment based on patient characteristics has led to the development of therapeutic strategies that target specific cancer-related molecular pathways, including epidermal growth factor receptor (EGFR), angiogenesis, and anaplastic lymphoma kinase inhibitors. Current research is focused on combining targeted therapy with platinum-based chemotherapy in an endeavor to achieve an additional benefit in specific patient populations. Currently, pemetrexed is indicated for use in the first-line, maintenance, and second-line settings for the treatment of nonsquamous NSCLC. The combination of pemetrexed and cisplatin is well tolerated and is the approved standard first-line therapy. Thus, the pemetrexed-platinum backbone provides an attractive option for combination with targeted therapies. This review aims to summarize the current knowledge and future prospects of the use of pemetrexed-platinum as a backbone for combination with targeted therapies for NSCLC.
KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
KW - Carcinoma, Non-Small-Cell Lung/drug therapy
KW - ErbB Receptors/antagonists & inhibitors
KW - Humans
KW - Lung Neoplasms/drug therapy
KW - Molecular Targeted Therapy
KW - Pemetrexed/administration & dosage
KW - Platinum/administration & dosage
UR - http://www.scopus.com/inward/record.url?scp=84953370158&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000367538900001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.cllc.2015.07.002
DO - 10.1016/j.cllc.2015.07.002
M3 - Review article
C2 - 26340853
SN - 1525-7304
VL - 17
SP - 1
EP - 9
JO - Clinical Lung Cancer
JF - Clinical Lung Cancer
IS - 1
ER -