Paradoxical control of multifocal mammary oncogenesis by radiation therapy

Lorenzo Galluzzi; Aitziber Buqué

doi:10.1080/2162402X.2025.2458886

Paradoxical control of multifocal mammary oncogenesis by radiation therapy

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Abstract

In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood.

Original language	English
Article number	2458886
Pages (from-to)	2458886
Journal	Oncoimmunology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2025.2458886
State	Published - Jan 28 2025

Keywords

Animals
Female
Mice
Carcinogenesis/radiation effects
Mammary Neoplasms, Experimental/radiotherapy
Humans
Breast Neoplasms/radiotherapy
CD4 CD25 FOXP3 T cells
IL-1β
dendritic cells
immunotherapy
CTLA4
PD-1

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10.1080/2162402X.2025.2458886

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title = "Paradoxical control of multifocal mammary oncogenesis by radiation therapy",

abstract = "In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood.",

keywords = "Animals, Female, Mice, Carcinogenesis/radiation effects, Mammary Neoplasms, Experimental/radiotherapy, Humans, Breast Neoplasms/radiotherapy, CD4 CD25 FOXP3 T cells, IL-1β, dendritic cells, immunotherapy, CTLA4, PD-1",

author = "Lorenzo Galluzzi and Aitziber Buqu{\'e}",

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AU - Buqué, Aitziber

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N2 - In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood.

AB - In an immunocompetent mouse model of multifocal, metachronous HR+ mammary carcinogenesis, we have recently demonstrated that a superior control of primary neoplastic lesions by focal radiotherapy does not necessarily translate into improved oncosuppression at non-irradiated (pre)malignant tissues. These data point to a link between local tumor control by radiotherapy and systemic oncogenesis that remains to be fully understood.

KW - Animals

KW - Female

KW - Mice

KW - Carcinogenesis/radiation effects

KW - Mammary Neoplasms, Experimental/radiotherapy

KW - Humans

KW - Breast Neoplasms/radiotherapy

KW - CD4 CD25 FOXP3 T cells

KW - IL-1β

KW - dendritic cells

KW - immunotherapy

KW - CTLA4

KW - PD-1

UR - https://www.scopus.com/pages/publications/85216363634

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DO - 10.1080/2162402X.2025.2458886

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JO - Oncoimmunology

JF - Oncoimmunology

IS - 1

M1 - 2458886

ER -

Paradoxical control of multifocal mammary oncogenesis by radiation therapy

Abstract

Keywords

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